Research progress of respiratory tract infection induced by respiratory syncytial virus in children / 国际儿科学杂志

Respiratory syncytial virus (RSV) is a major cause of respiratory tract infection in children,and RSV infection is an important inducement to recurrent cough or wheezing in children.Nevertheless,the pathogenes is not clear,the clinical presentations are significantly different.Its test is not effective and fast,and the positive therapies to control RSV airway infection are lacking.Therefore,to control the respiratory tract disease of the children,it is important to know the research progress of the pathogenesis,the clinical manifestation,the examination,and the prevention and therapy of RSV infection.

Congenital preauricular fistula infection: a histopathology observation / 临床耳鼻咽喉头颈外科杂志

OBJECTIVE@#To investigate the pathology characteristics of congenital preauricular fistula with infection, in order to reduce the recurrence rate after surgery and improve operative technique.@*METHOD@#Twenty-five patients diagnosed as congenital preauricular fistula with infection were analyzed. There were 14 patients in infection history group, 9 in infective stage group, and 2 in recurrence group respectively. The whole piece of fistula and scar tissue was completely excised during operation. The specimens were observed by naked eye and serial tissue sections were analyzed.@*RESULT@#(1) Macroscopically, in infection history group, initial morphology can be maintained near the fistula orifice, but the distal tissue was dark red scar tissue. In infective stage group, the distal tissue of the specimens was granulation tissue and cicatricial tissue. The granulation tissue was crisp and bright red. In recurrence group, multicystic lesions with severe edema was observed, with a classical dumb-bell appearence. (2) Microscopically, in infection history group and recurrence group, we can see that the distal fistula tissue was discontinuous and was separated by scar tissue. In infective stage group, we can find neo-angiogenesis and infiltration of plasma cells, lymphocytes, neutrophil between interrupted fistula tissues. (3) All patients were followed up for 6-12 month, without recurrence.@*CONCLUSION@#The fistula tissue of congenital preauricular fistula with infection was divided by the scar tissue, and they did not communicate with each other. Complete delineation of fistula is hardly achieved by methylene blue staining. Radical excision of the fistula and scar tissue may help to avoid leaving viable squamous epithelial remnants and reduce the recurrence rate.

Progress of human rhinovirus infection and asthma / 国际儿科学杂志

Human rhinovirus(HRV)is a common pathogen causing respiratory tract infection.and recent studies have shown that HRV infection is not only a cause of asthma acute exacerbation.but their early infection in infants and young children also plays an important role during the formation of asthma in children.HRV causes asthma relevant symptoms mainly by the following mechanisms,infection of bronchial epitheIial cells.to promote the release of inflammatory mediators.the immune response and to cause airway remodeling.Learning more about the impact of HRV infection on asthma and related mechanisms will help US to find effective prevention and treatment methods to reduce asthma morbidity and acute excerbation.