RESUMO
An LH-RH agonist, des-Gly10, [DTrp6]-LH-RH ethylamide (LH-RH A), was administered chronically to adult male cats in order to determine its effect on the steroidogenesis of the testis during the stimulatory action of human chorionic gonadotropin (hCG). Measurement of plasma testosterone levels were combined with the histochemical analysis of some steps of the testicular steroidogenic pathway. Chronic daily treatment with LH-RH A(20 *g/kg) for 67 days inhibited the early testicular response to hCG during the initial 0.5,1 and 24 h, whereas the inhibitory egffect was not observed 48 and 72 h after hCG administration.The maximal responses to hCG were obtained both in LH-RH A-treated animals and in their control group 48 and 72 h after hCG adnministration. Under these conditions, LH-RH A-treated cats showed no alteration in 3ß-hydroxysteroid dehydrogenase (3ß-Host-D) activity, whereas a marked inhibition was observed in the activity of alcohol dehydrogenase (ADII) which reflects the activity of 20,22-desmolase and/or 17,20-desmolase.
Assuntos
Gatos , Animais , Masculino , Gonadotropina Coriônica/farmacologia , Hormônio Liberador de Gonadotropina/análogos & derivados , Esteroides/metabolismo , Testículo/fisiologia , Testosterona/metabolismo , Testosterona/sangueAssuntos
Ratos , Animais , Feminino , 17-Hidroxiesteroide Desidrogenases/metabolismo , Peso Corporal/efeitos dos fármacos , Tamanho do Órgão/efeitos dos fármacos , Ovário/efeitos dos fármacos , Síndrome do Ovário Policístico/fisiopatologia , Maturidade Sexual/efeitos dos fármacos , Testosterona/farmacologia , Ovário/patologia , Ratos EndogâmicosRESUMO
Após breve revisäo da legislaçäo brasileira referente à pós-graduaçäo na área médica, descreve-se a adaptaçäo dessa legislaçäo aos programas de Mestrado e Doutorado em Patologia Humana da Faculdade de Medicina de Ribeiräo Preto, bem como a experiência acumulada nos últimos 6 anos e as perspectivas desses programas