Effect of serum uric acid on nonalcoholic fatty liver disease in different genders / 中华全科医师杂志

Nonalcoholic fatty liver disease (NAFLD) now has become a disease threatening people′s health, but there is no effective treatment for it at present,so early prevention and control of risk factors of NAFLD is particularly important. Hypertension, hyperlipidemia, hyperglycemia are associated with the risk of NAFLD;in recent years serum uric acid has also been recognized as a risk factor for NAFLD;however,there is a gender discrepancy in its impact on NAFLD. This article reviews the relevant research progress in recent years to elaborate the effect of serum uric acid on NAFLD in different genders.

Study on Optimization of the Nine-time Repeat Steaming and Sun-drying Process Processing Technology of Polygonum multiflorum / 中国药房

OBJECTIVE：To establish methods for the content determination of stilbene glycoside ，emodin，emodin methyl ether and total polysaccharide in P. multiflorum ，and to optimize the processing technology of traditional nine-time repeat steaming and sun-drying process of P. multiflorum . METHODS ：HPLC method was adopted to determine the contents of stilbene glycoside ， emodin，and emodin methyl ether. The content of total polysaccharide was determined by UV spectrometry. With steaming time ， drying time and drying temperature as independent variables ，the contents of stilbene glycoside ，emodin，emodin methyl ether and total polysaccharide as indexes ，the processing technology of nine-time repeat steaming and sun-drying process of P. multiflorum was optimized by weighted comprehensive score method and central composite design-response surface method ，and the validation tests were conducted. RESULTS ：The linear range of sample size of stilbene glycoside ，emodin and emodin methyl ether were 0.27-2.7 µg（r＝0.997 1），0.063-0.63 µg（r＝0.999 9），0.038-0.38 µg（r＝0.990 9），respectively. The linear range of mass concentration of total polysaccharide was 2.07-12.42 µg/mL（r＝0.999 6），respectively. RSDs of precision ，stability and reproducibility tests were all lower than 2％. The recoveries were 99.43％-101.06％（RSD＝0.63％，n＝6），98.74％-120.33％ （RSD＝1.34％，n＝6），98.39％-102.44％（RSD＝1.49％，n＝6），99.51％-101.98％（RSD＝0.87％，n＝6），respectively. The optimal processing technology was steaming time for 4.5 h，drying time for 9 h，drying temperatrue for 66 ℃ and repeat processing for 9 times. Results of 3 times of validation tests showed that the comprehensive score of optimal technology was 35.69， relative error of which to predicted value （36.90）was 3.30％. CONCLUSIONS ：Established method is simple and reproducible ， and the optimal processing technology is predicive ，stable feasible.