Advances in the research on relationship between p27Kip1 and digestive tumors / 中国癌症杂志

p27kip1 maps 12p13 and it has two exons. p27 not only inhibits the activation of acyclin dependent kinases, but also surpress the activity of ctivated cyclin CDKs. p27 plays a key role in the regulation of cell cycle progression, and relates to cell differentiation and apoptosis. Loss of p27 protein or lower level of it is prevalent in digestive tumors, and reduction of p27kip1 protein indicates malignant prognosis.