Autoimmune hepatitis-related autoantibodies and their clinical significance / 临床肝胆病杂志

Autoimmune hepatitis (AIH) is an autoimmune response-mediated liver parenchymal inflammation targeting hepatocytes, with the features of autoantibodies in serum, a high serum level of immunoglobulin G, and/or hypergammaglobulinemia. Most AIH patients have one or more autoantibodies in serum, and these antibodies are important features of AIH and the basis for the diagnosis of AIH. Some antibodies are also associated with the clinical manifestations, disease activity, therapeutic response, and prognosis of AIH. This article reviews AIH-related autoantibodies and their clinical significance.