RESUMO
Allergic contact dermatitis （ACD）is a common type Ⅳ allergic disease ，which has a wide range of patients ，and seriously affects the quality of patients ’lives. To understand the pharmacological mechanism of traditional Chinese medicine （TCM）in the treatment of ACD ，and to provide reference for clinical application and new drug research and development ，the relevant research literatures were reviewed from aspects of pathogenesis of ACD ，traditional Chinese medicine that can be used to treat ACD and its mechanism of action. TCM for the treatment of ACD mainly include heat-clearing medicines （Sophora flavescens，Dictamnus dasycarpus ），exterior-releasing medicines （Cinnamomum cassia ，Xanthium sibiricum ，Saposhnikovia divaricata），antirheumatic medicines （Tripterygium wilfordii ，Cynanchum paniculatum ），and damp-draining medicines （Plantago asiatica，Kochia scoparia ），etc. The main mechanisms include inhibition of IgE secretion ，regulation of Th 1/Th2 cell and Th 17/ Treg balance ，reduction of mast cells degranulation ratio ，inhibition of pERK 1/2/TLR4/NF-κ B pathway，AIM2/caspase-1 inflammasome signaling pathway ，Wnt/β-catenin pathway ，STAT3 pathway and MAPK pathway.
RESUMO
Aims Tocomparethepharmacokineticsof ephedra alkaloids,cinnamic acid and cinnamic alcohol in Ephedrae, Cinnamomi and Ephedrae-Cinnamomi herb couple through UPLC-MS/MS in rats respective-ly,and to investigate the effect of combination on phys-iologicaldisposition.Methods Plasmasampleswere collected at different times after oral administration of Ephedrae,Cinnamomi and Ephedrae-Cinnamomi herb couple extracts.The concentrations of ephedra alka-loids,cinnamic acid and cinnamic alcohol in plasma samples were determined by UPLC-MS/MS.DAS 3. 0 was used to calculate pharmacokinetic parameters.The differences of samples in two groups were conducted with univariate statistical analysis using SPSS 13. 0. Results ComparedwithEphedraegroup,theCmaxof norephedrine hydrochloride, norpseudoephedrine hydrochloride,ephedrine hydrochloride,pseudoephed-rine hydrochloride,and methylephedrine hydrochloride in Ephedrae-Cinnamomi herb couple group were signif-icantly greater (P<0. 05 );the AUC0-t of norpseudo-ephedrine hydrochloride was significantly greater (P<0. 05 );the MRT0-t of norephedrine hydrochloride, phedrine hydrochloride, pseudoephedrine hydrochlo-ride,and methylephedrine hydrochloride were signifi-cantly less (P <0. 05 );the T1/2z of norephedrine hydrochloride,phedrine hydrochloride,and methyl-ephedrine hydrochloride were significantly less (P <0. 05 ).The AUC0-t and MRT0-t of cinnamic acid and cinnamic alcohol were significantly greater than those inCinnamomigroup(P<0.05).Conclusion The combination of Ephedrae and Cinnamomi improves the absorption concentration of five ephedra alkaloids, Slows down the elimination of norephedrine hydrochlo-ride,phedrine hydrochloride,pseudoephedrine hydro-chloride,and methylephedrine hydrochloride,and in-creases the bioavailability of cinnamic acid and cin-namic alcohol.