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Clinics ; 66(4): 543-547, 2011. tab
Artigo em Inglês | LILACS | ID: lil-588901

RESUMO

OBJECTIVE: This study examined the antimicrobial resistance profile and the prevalence of resistance genes in Bacteroides spp. and Parabacteroides distasonis strains isolated from children's intestinal microbiota. METHODS: The susceptibility of these bacteria to 10 antimicrobials was determined using an agar dilution method. β-lactamase activity was assessed by hydrolysis of the chromogenic cephalosporin of 114 Bacteriodales strains isolated from the fecal samples of 39 children, and the presence of resistance genes was tested using a PCR assay. RESULTS: All strains were susceptible to imipenem and metronidazole. The following resistance rates were observed: amoxicillin (93 percent), amoxicillin/clavulanic acid (47.3 percent), ampicillin (96.4 percent), cephalexin (99 percent), cefoxitin (23 percent), penicillin (99 percent), clindamycin (34.2 percent) and tetracycline (53.5 percent). P-lactamase production was verified in 92 percent of the evaluated strains. The presence of the cfiA, cepA, ermF, tetQ and nim genes was observed in 62.3 percent, 76.3 percent, 27 percent, 79.8 percent and 7.8 percent of the strains, respectively. CONCLUSIONS: Our results indicate an increase in the resistance to several antibiotics in intestinal Bacteroides spp. and Parabacteroides distasonis and demonstrate that these microorganisms harbor antimicrobial resistance genes that may be transferred to other susceptible intestinal strains.


Assuntos
Criança , Humanos , Antibacterianos/farmacologia , Bacteroides/efeitos dos fármacos , Farmacorresistência Bacteriana/genética , Intestinos/microbiologia , Análise de Variância , Bacteroides/genética , Bacteroides/isolamento & purificação , Farmacorresistência Bacteriana/efeitos dos fármacos , Genes Bacterianos/efeitos dos fármacos , Genes Bacterianos/genética , Imipenem/farmacologia , Testes de Sensibilidade Microbiana , Metronidazol/farmacologia
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