Ocular manifestations in adolescent cystinosis: case report in Thailand.

Three siblings with a family history of consanguinity presented with short stature and two of the patients had leg deformity. None of them experienced ocular or renal symptoms at presentation. After the pediatricians found characteristics of Fanconi syndrome, an ophthalmic consultation was requested Ocular examination revealed typical cystine crystals deposited in the cornea and conjunctivae. No crystal deposits were found elsewhere in the eyes. Fundoscopic examination was normal. Two patients who underwent a complete ocular examination were diagnosed as adolescent cystinosis. The youngest patient who lost to follow up before completed ocular examination was suspected for adolescent cystinosis. This is the first report of cystinosis with ocular manifestation from Thailand.

Efficacy of brimonidine 0.2 per cent as adjunctive therapy to beta-blockers: a comparative study between POAG and CACG in Asian eyes.

OBJECTIVE: To compare the efficacy and safety profile of brimonidine as adjunctive therapy to beta-blockers between primary open angle glaucoma (POAG) and chronic angle closure glaucoma (CACG) in Asian eyes. DESIGN: Three-months, open-label, prospective study. PARTICIPANTS: Twenty-three patients (35 eyes) with POAG and 25 patients (39 eyes) with CACG were enrolled in the study. INTERVENTION: Patients with POAG or CACG post iridectomy whose IOP was inadequately controlled with topical beta-blocker monotherapy were included. Then, brimonidine 0.2 per cent was added twice daily in both groups. Study visit occurred at weeks 2, 4, 8, and 12. Complete ophthalmic examinations were performed in all visits. MAIN OUTCOME MEASURES: Efficacy was determined by reduction in IOP from baseline and tolerability was assessed by reports of adverse events. RESULTS: After 3 months of brimonidine adjunctive treatment, the mean (+/- SEM) IOP reduction were 4.37+/-0.34 mmHg (19.4%) in POAG and 4.54+/-0.37 mmHg (20.1%) in CACG (p= 0.741). No serious ocular or systemic adverse event was reported. CONCLUSION: Brimonidine was well tolerated, efficacious and provided additive IOP reduction in POAG and CACG.

Evaluation of screening tests and prevalence of glaucoma: integrated health research program for the Thai elderly.

The purposes of this study were to evaluate the accuracy of glaucoma screening tests and to assess the prevalence of glaucoma in an elderly Thai population over 60 years of age. This was a cross-sectional study. 3706 subjects were recruited from 33 communities in the vicinity of Siriraj Hospital. All received an eye examination from ophthalmologists and general practitioners including visual acuity, Schiotz tonometry and optic disc evaluation in their residential communities. Subjects who were suspected of having glaucoma were re-examined at the Glaucoma Clinic, Siriraj Hospital. They were then classified as having definite glaucoma of a specific type or as not having glaucoma. The overall prevalence of glaucoma was 6.1 per cent (128/2092). The percentages of primary open angle glaucoma, primary angle closure glaucoma, normotension glaucoma and secondary glaucoma were 47.7 per cent, 41.4 per cent, 9.4 per cent, and 1.6 per cent respectively. The sensitivity and specificity of the screening tests performed by ophthalmologists were 100 per cent and 97.2 per cent and those performed by general practitioners were 21.7 per cent and 96.5 per cent.