Level of Auto Antibody Against Oxidized LDL in Myocardial Infracted Patients.

The aim of this study was to evaluate the level of auto antibody against oxidized LDL in myocardial infracted (MI) patients and normal healthy subjects of West Bengal (India) and to establish it to be also a cofactor for MI. Patients and Methodology : This study was carried out on 285 patients with MI as well as 75 healthy volunteers of comparable age and gender as control group. Blood was collected immediately after admission of the patients. Auto antibody against oxidized LDL, Nitric Oxide and malondialdehyde (MDA) were measured in all groups. Results : Mean serum level of auto antibody against oxidized LDL, MDA, total Cholesterol and LDL Cholesterol levels (118 ± 9.0, 7.4 ± 1.3, 233 ± 30, and 145 ± 38) were significantly (p<0.05) higher in MI patients when compared with control subject. The mean serum levels of nitric oxide (NO) and HDL, cholesterol were significantly (p<0.05) lower as compared to control group. Conclusion : Significantly high level of auto antibody against oxidized LDL associated with high level of MDA, total cholesterol and decreased level of NO and HDL cholesterol appear to be the factors responsible for the increase risk of coronary artery disease i.e., myocardial infarction in the population of West Bengal, India.

Morphometric and Macroscopic Observations of Human Placenta in Eclampsia.

Objective: To assess some macroscopic changes in the placentas of eclamptic mothers in a tertiary care setting of eastern India. Design: Cross-sectional observational type of study. Methods: 44 placentas from 15 normotensive and 29 eclamptic mothers were collected after delivery at term and studied for area, weight and volume. Foetal surface was studied for insertion of umbilical cord, insertion of membranes and subchorionic fibrosis. Maternal surface was studied for retroplacental blood clot, calcification and infarct. Necessary statistical tests were done. Result: Statistically significant differences were observed in placental area, weight and volume between normotensive and eclamptic mothers. These showed that placental area, weight and volume were more in the former group with some exceptions. Subchorionic fibrosis, retroplacental blood clot, calcification and infarct were also more in placentas of eclamptic mothers. Conclusion: Eclampsia adversely affects the foetus through its harmful effects on placenta. The study agrees well with the findings of other investigators.