RESUMO
BACKGROUND: The current diagnosis of hereditary non-polyposis colorectal cancer (HNPCC) is dependent on a detailed family history based on the Amsterdam criteria proposed by the International Collaborative Group on HNPCC (ICG-HNPCC) in 1990. On recognizing the shortcomings of the ICG-HNPCC criteria, the Korean Hereditary Colorectal Cancer Registry (a subdivision of the Korean Hereditary Tumor Registry) designated the term 'suspected HNPCC' for families who do not fullfill the criteria of the ICG-HNPCC but in whom a genetic basis for colon cancer is strongly suggested. The present study was designed to determine the frequency and define the clinical characteristics of suspected HNPCC. METHODS: We analysed the clinical characteristics of 42 suspected HNPCC patients and their family members and compared these characteristics with that of 1,692 non-hereditary colorectal cancer patients. RESULTS: The frequency of suspected HNPCC was 2.4% in our study. The mean age of suspected HNPCC patients at the time of diagnosis was 45.1+/-9.6 years and that of non-hereditary colorectal cancer patients was 57.4+/-11.9 years. The incidence of synchronous colorectal cancers in HNPCC was 7.1% and that of non-hereditary colorectal cancers was 0.9%. In suspected HNPCC families, 18 patients had extracolonic malignancies and the stomach cancer was the most common (55.5%).CONCLUSION: The frequency of suspected HNPCC among total colorectal cancer cases was 2.4% in our study. Tumors in suspected HNPCC differed from non-hereditary colorectal cancers in an early age of onset.
Assuntos
Humanos , Idade de Início , Neoplasias do Colo , Neoplasias Colorretais , Diagnóstico , Incidência , Neoplasias GástricasRESUMO
Pneumatosis cystoides intestinalis (PCI) is defined as the presence of multiple gas filled cysts in the wall of gastrointestinal tract, and was first reported by Duvernoi in 1730 from the pathologic findings at autopsy. The etiology and pathogenesis of this relatively rare but distinctive disorder remain unresolved. We recently experienced a case of PCI, in a 28-year old woman with chronic constipation for about 10 years. The case is presented with review of the literature.