Risk and Risk Factors for Postpartum Type 2 Diabetes Mellitus in Women with Gestational Diabetes: A Korean Nationwide Cohort Study

Background@#There are differences in risk and risk factor findings of postpartum type 2 diabetes mellitus (T2DM) after gestational diabetes depending on study design and subjects of previous studies. This study aimed to assess these risk and risk factors more accurately through a population-based study to provide basic data for prevention strategies. @*Methods@#This open retrospective cohort included data of 419,101 women with gestational diabetes and matched 1,228,802 control women who delivered between 2004 and 2016 from the South Korea National Health Information Database of the National Health Insurance Service. Following 14 (median 5.9) years of follow-up, the incidence and hazard ratio (HR) of postpartum T2DM were evaluated using Kaplan-Meier curves and Cox proportional regression models. @*Results@#The incidence and HR of postpartum T2DM in women with gestational diabetes (compared to women without gestational diabetes) after the 14-year follow-up was 21.3% and 2.78 (95% confidence interval [CI], 2.74 to 2.82), respectively. Comorbid obesity (body mass index [BMI] ≥25 kg/m2) increased postpartum T2DM risk 7.59 times (95% CI, 7.33 to 7.86). Significant risk factors for postpartum T2DM were fasting glucose level, BMI, age, family history of diabetes, hypertension, and insulin use during pregnancy. @*Conclusion@#This population-based study showed higher postpartum T2DM risk in women with gestational diabetes than in those without, which was further increased by comorbid obesity. BMI and fasting glucose level were important postpartum risk factors. The management of obesity and glycemic control may be important strategies to prevent the incidence of diabetes after delivery.

Effect of secondhand smoking on gingival pain and bleeding in non-smoking adolescents in South Korea / 대한구강보건학회지

Objectives@#This study aimed to identifying the relationship between exposure to secondhand smoking and oral diseases in adolescents, based on the web-based youth health risk behavior survey from 2020. @*Methods@#Among the 54,948 adolescent respondents to the 16th youth health risk behavior survey in 2020, this study included a total of 48,867 non-smoking adolescent participants who had never used regular cigarettes, vapes, or e-cigarettes. Analysis of the complex sample survey data was performed by applying weights according to the complex sample provided by the Korea Disease Control and Prevention Agency. Cross-tabulation analysis by complex sampling using the RaoScott chi-square test and complex-sample t-test was then performed to identify the relationship between subject characteristics and gingival pain and bleeding prevalence. Finally, a binary logistic regression analysis was performed to determine the effects of secondhand smoking on symptoms of gingival pain and bleeding in non-smoking adolescents. Data were analyzed using SPSS 26.0 version, and the statistical significance level was defined as P<0.05. @*Results@#Among the participants, periodontal disease symptoms were reported 1.201 times (95% confidence interval [CI]: 1.101-1.310) more often in those with exposure to secondhand smoking exposure at home and 1.281 times (95% CI: 1.173-1.398) more often in those with exposure to secondhand smoking in public places than in those who did not report exposure to secondhand smoking. @*Conclusions@#The study results suggest that exposure to secondhand smoking increases the risk of gingival pain and bleeding in non-smoking South Korean adolescents and is a risk factor for periodontal diseases.

Effect of secondhand smoking on gingival pain and bleeding in non-smoking adolescents in South Korea / 대한구강보건학회지

Objectives@#This study aimed to identifying the relationship between exposure to secondhand smoking and oral diseases in adolescents, based on the web-based youth health risk behavior survey from 2020. @*Methods@#Among the 54,948 adolescent respondents to the 16th youth health risk behavior survey in 2020, this study included a total of 48,867 non-smoking adolescent participants who had never used regular cigarettes, vapes, or e-cigarettes. Analysis of the complex sample survey data was performed by applying weights according to the complex sample provided by the Korea Disease Control and Prevention Agency. Cross-tabulation analysis by complex sampling using the RaoScott chi-square test and complex-sample t-test was then performed to identify the relationship between subject characteristics and gingival pain and bleeding prevalence. Finally, a binary logistic regression analysis was performed to determine the effects of secondhand smoking on symptoms of gingival pain and bleeding in non-smoking adolescents. Data were analyzed using SPSS 26.0 version, and the statistical significance level was defined as P<0.05. @*Results@#Among the participants, periodontal disease symptoms were reported 1.201 times (95% confidence interval [CI]: 1.101-1.310) more often in those with exposure to secondhand smoking exposure at home and 1.281 times (95% CI: 1.173-1.398) more often in those with exposure to secondhand smoking in public places than in those who did not report exposure to secondhand smoking. @*Conclusions@#The study results suggest that exposure to secondhand smoking increases the risk of gingival pain and bleeding in non-smoking South Korean adolescents and is a risk factor for periodontal diseases.

Malvidin Protects WI-38 Human Fibroblast Cells Against Stress-induced Premature Senescence

BACKGROUND: Malvidin is one of the most abundant components in red wines and black rice. The effects of malvidin on aging and lifespan under oxidative stress have not been fully understood. This study focused on the anti-aging effect of malvidin on stress-induced premature senescence (SIPS) in WI-38 human lung-derived diploid fibroblasts. METHODS: In order to determine the viability of WI-38 cells, MTT assay was conducted, and malondialdehyde level was determined using thiobarbituric acid-reactive substance assay. Protein expression of inflammation-related factors was also evaluated by Western blot analysis. RESULTS: Acute and chronic oxidative stress via hydrogen peroxide (H2O2) treatment led to SIPS in WI-38 cells, which showed decreased cell viability, increased lipid peroxidation, and a shortened lifespan in comparison with non-H2O2-treated WI-38 cells. However, malvidin treatment significantly attenuated H2O2-induced oxidative stress by inhibiting lipid peroxidation and increasing cell viability. Furthermore, the lifespan of WI-38 cells was prolonged by malvidin treatment. In addition, malvidin downregulated the expression of oxidative stress-related proteins, including NF-κB, COX-2, and inducible nitric oxide synthase. Furthermore, protein expression levels of p53, p21, and Bax were also regulated by malvidin treatment in WI-38 cells undergoing SIPS. CONCLUSIONS: Malvidin may potentially inhibit the aging process by controlling oxidative stress.

The Effects of Dumbbell, Walking, and Yoga Exercise Interventions for the Community-Dwelling Women / 성인간호학회지

PURPOSE: The purpose of this study was to examine the effects of exercise intervention, including dumbbell(weight lifting), walking, and yoga, on the body composition, physiologic factors, body image, and perceived health in the community-dwelling women. METHOD: This study utilized pretest-posttest design with three types of exercise interventions. The types of exercise intervention included dumbbell, walking, and yoga. RESULTS: A total of 136 subjects were included: 49 for dumbbell, 67 for walking, and 20 for yoga. As measures of body composition, BMI, body weight, and body fat rate were significantly improved only after dumbbell intervention(p.05) and none of the measures for perceived health state were not significantly changed in all groups(p>.05). CONCLUSION: From the findings of this study, it was demonstrated that the effects of exercise interventions were differentiated by their types and variables to be affected. Therefore, future studies that apply the tailored exercise intervention to each age-categorical group are needed.

The Effects of Dumbbell, Walking, and Yoga Exercise Interventions for the Community-Dwelling Women / 성인간호학회지

PURPOSE: The purpose of this study was to examine the effects of exercise intervention, including dumbbell(weight lifting), walking, and yoga, on the body composition, physiologic factors, body image, and perceived health in the community-dwelling women. METHOD: This study utilized pretest-posttest design with three types of exercise interventions. The types of exercise intervention included dumbbell, walking, and yoga. RESULTS: A total of 136 subjects were included: 49 for dumbbell, 67 for walking, and 20 for yoga. As measures of body composition, BMI, body weight, and body fat rate were significantly improved only after dumbbell intervention(p.05) and none of the measures for perceived health state were not significantly changed in all groups(p>.05). CONCLUSION: From the findings of this study, it was demonstrated that the effects of exercise interventions were differentiated by their types and variables to be affected. Therefore, future studies that apply the tailored exercise intervention to each age-categorical group are needed.