RESUMO
Background: Radio-iodine is a definite therapy for Graves disease hyperthyroidism. However, the optimal dosage is still debatable. Aim: To assess the effects of different radioiodine doses on thyroid function and complications in patients with hyperthyroidism. Material and methods: A retrospective analysis of 139 patients with hyperthyroidism, treated with ratioiodine between 1988 and 1998. Radio iodine dose used was classified as low (<10 mCi), intermediate (10-14.9 mCi) or high (ü 15 mCi). Results: Thirty five patients were treated with low doses, 33 with intermediate doses and 71 with high doses. There were no differences between these patients in age, disease severity, frequency of post treatment euthyroidism or complications. Patients treated with low doses had a higher frequency of persistent hyperthyroidism than patients treated with high doses (25.7 and 4.2 percent respectively, p<0,001). Likewise, the frequency of subsequent hypothyroidism was 60 percent in patients treated with low doses and 84.5 percent of those with high doses, in whom it also appeared earlier. Associated complications were clinically irrelevant. In seven patients, Graves ophtalmopathy progressed after treatment, but this progression was not associated with the dose used. Conclusions: Radio iodine in high doses is useful, safe and effective for the treatment of Graves hyperthyroidism
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Hipertireoidismo/radioterapia , Radioisótopos do Iodo/administração & dosagem , Doença de Graves/radioterapia , Dosagem Radioterapêutica , Glândula Tireoide/efeitos da radiação , Relação Dose-Resposta à RadiaçãoRESUMO
Esta revisión describe los avances más recientes en el diagnóstico y tratamiento del carcinoma diferenciado de tiroides. Esta neoplasia tiene una morbilidad relativamente elevada. Se presentan los principales procedimientos diagnósticos, haciendo énfasis en los estudios morfológicos y citológicos disponibles. Las diferentes modalidades terapéuticas, médicas y quirúrgicas son expuestas. Se discuten las ventajas y desventajas de los procedimientos quirúrgicos más utilizados. Se incluyen temas controversiales como la indicación de tiroidectomía subtotal en tumores de "buen iagnóstico", el uso del yodo 131 para terapia ablativa y las complicaciones asociadas a la terapia supresora con hormona tiroidea
Assuntos
Humanos , Nódulo da Glândula Tireoide/diagnóstico , Neoplasias da Glândula Tireoide/diagnóstico , 3-Iodobenzilguanidina/uso terapêutico , Nódulo da Glândula Tireoide/cirurgia , Prognóstico , Neoplasias da Glândula Tireoide/tratamento farmacológico , Neoplasias da Glândula Tireoide/cirurgia , TireoidectomiaRESUMO
Traditionally, Basedow graves disease was considered a protection against cancer. However, recent reports suggest that cancer occurs with a higher frequency than expected and is more aggressive in this disease. We report six patients with hyperthyroidism due to a Basedow Graves disease that presented a palpable thyroid nodule, which was cold in the scintiscan and solid in the ultrasound examination. Fine needle cytology disclosed cancer in 5 cases (2 with cytological features of greater aggressiveness) and a nodular hyperplasia in one. The diagnosis was confirmed in the surgical piece in all patients. We conclude that Basedow Graves disease and thyroid cancer, which can have an increased aggressiveness, may coexist