Effect of gamma-interferon on fibroblast proliferation and collagen synthesis after glaucoma filtering surgery in white rabbits

Failure of a glaucoma filtering operation mainly results from scarring at the filtering wound, and postoperative proliferation and migration of fibroblasts play an important role histologically in the formation of scar tissue. As an inhibitory agent for fibroblast proliferation, gamma-interferon has been introduced, and the application of gamma-interferon following filtering surgery is now being made on a trial basis. We studied the effect of gamma-interferon histologically on the fibroblast proliferation and collagen synthesis occurring at the filtering site by comparing the effect of gamma-interferon on the experimental group with that of 5-fluorouracil on the control group, using 10 rabbits (20 eyes) after posterior lip sclerectomy. Both groups showed similar flat and diffused bleb grossly and also showed a similar inhibitory effect on fibroblast proliferation and collagen fiber synthesis histologically. Our findings seem to justify the clinical use of gamma-interferon. Further studies on adequate dosage, method of administration, and local and systemic complications would be desired.

Myopic Correction in Radial Keratotomy According to the Size of Central Optical Zone and Incision Length

We performed eight radial line cuts in anterior radial keratotomy(RK) employing the Russian style and the American style incisions on 103 eyes from August/ 1989 to March/ 1990. To analyze the results of myopic correction according to the size of the central optical zone and the incision length in RK, we chose the central optical zone size according to the degree of myopia (4.0 mm from -1.50D to -2.75D, 3.5mm from -30D to -3.75D and 3.0mm above -4.0D) and measured the length of each of the eight radial incisions of the cornea. The results were as follows: 1. In determining the average length of each corneal incision in RK, the longest was the superior and superior-nasal incision and the shortest was the temporal and inferior-temporal incision, regardless of the central optical zone size. 2. The total length of each of the eight incisions in each eye ranged from the longest at 3.0mm of central optical zone and the shortest at 4.0mm of central optical zone Undoubtedly, total incision length affected clinical results not significantly (p>0.05). 3. Assessing the clinical effect of myopic correction according to the optical zone size, smaller diameter clear zones produce a greater flattening of the cornea than larger ones. 4. The clinical result was not significantly affected by the direction of the incision (p>0.05).