Synthesis of mono-carbonyl curcumin analogues containing nitrogen heterocyclic ring and their anti-inflammatory activities / 中草药

Objective: A series of mono-carbonyl curcumin analogues containing nitrogen heterocyclic ring were designed and synthesized and their anti-inflammatory activities were detected. Methods: A mixture of thiophen-2-acryloyl chloride and compounds containing nitrogen heterocyclic ring reacted to yield the target compounds, and the structures were identified using 1H-NMR and ESI-MS. The anti-inflammatory activity of these compounds was detected by mouse macrophages producing pro-inflammatory cytokines TNF-α and IL-6 induced by LPS. Results: Thirteen target compounds were synthesized, and some of these compounds could significantly inhibit the production of inflammatory cytokines, especially compound Z5 exhibited the most inhibitory activity. Conclusion: Compounds Z1, Z5, and Z9-Z13 are new compounds, and compound Z5 could be used as the candidate of anti-inflammatory drug.

Observation on therapeutic effect of electroacupuncture therapy for promoting consciousness of patients with coma / 中国针灸

<p><b>OBJECTIVE</b>To observe the promoting consciousness effect of electroacupuncture therapy on the patients with long-term coma caused by severe craniocerebral trauma.</p><p><b>METHODS</b>Twenty-nine cases with coma more than 3 weeks and Glasgow Coma Scales (GCS) of 8 or less were divided into an observation group (n=15) and a control group (n=14). They were treated with the same western medicine. In addition to ordinary treatment, the observation group was treated with electroacupuncture at Baihui (GV 20), Shuigou (GV 26), Yongquan (KI 1) etc. for 30 min and the needles were retained for 30 min, once each day.</p><p><b>RESULTS</b>The average awake time and awake rate were 40.1 days and 73.3% (11/15) respectively in the observation group, which were higher than 51.8 days and 28.6% (4/14) in the control group.</p><p><b>CONCLUSION</b>Electroacupuncture therapy combine with western medicine is more effective in improving consciousness of patients in coma caused by severe craniocerebral trauma.</p>

Prevalence of abnormity of blood lipid and associated factors in health examination population in Beijing / 中国医学科学杂志(英文版)

<p><b>OBJECTIVE</b>To investigate the prevalence of abnormity of blood lipid and associated factors in healthy population in Beijing.</p><p><b>METHODS</b>Totally, 38462 individuals who received health examination were enrolled in our study. We divided them into eight groups according to their ages. The levels of serum total cholesterol, triglyceride, high density lipoprotein cholesterol, and low density lipoprotein cholesterol were tested, and the relationship of blood lipid abnormity with body mass index (BMI) and fasting blood glucose was analyzed.</p><p><b>RESULTS</b>The incidences of hypercholesterolemia, hyperglyceridemia, low high-density lipoprotein cholesterolemia, and hyper low-density lipoprotein cholesterolemia presented increasing trend in this population. The incidence rate of abnormity of blood lipid in health examination population increased with BMI increase. The incidence of abnormity of blood lipid in overweight and obesity population was significantly higher than that in low weight and normal weight populations (P<0.05). Meanwhile, the trend of abnormal blood lipid incidence coincided with that of abnormal fasting blood glucose.</p><p><b>CONCLUSIONS</b>The prevalence of overweight, obesity, and abnormity of blood lipid in Beijing presents increasing trend. The incidence of abnormity of blood lipid increases with BMI increase, in coincidence with that of fasting blood glucose.</p>

Prevalence of metabolic syndrome and its associations with other metabolic disorders and cardiovascular changes in health examination population in Beijing / 中国医学科学杂志(英文版)

<p><b>OBJECTIVE</b>To investigate the prevalence of metabolic syndrome (MS) and its associations with other metabolic disorders and cardiovascular changes in health examination population in Beijing.</p><p><b>METHODS</b>Totally, 10,916 individuals who received health examination in Health Examination Center of Peking Union Medical College Hospital were enrolled. The height, weight, blood pressure, serum levels of triglyceride, high-density lipoprotein cholesterol (HDL-C), and fasting blood glucose were recorded. MS was diagnosed based on the working criteria of Chinese Diabetes Society 2004 (CDS2004). Meanwhile, other metabolic disorders, including fatty liver and hyperuricemia, were recorded. The cardiovascular changes were reflected by the reports of electrocardiogram (ECG) ST-T changes and atherosclerosis of retinal arteries.</p><p><b>RESULTS</b>The overall prevalence rate of MS was 6.1% (666/10,916) in the population. The prevalence rate of MS in male was much higher than that in female (9.0% vs. 2.7%, P=0.000). For individuals with MS, the prevalence rates of fatty liver and hyperuricemia were significantly higher than those without MS, respectively (70.4% vs. 35.4%, P=0.000; 29.9% vs. 17.7%, P=0.000). As for cardiovascular changes, the prevalence rates of ECG ST-T changes and atherosclerosis of retinal arteries were significantly higher in individuals with MS than those without MS, respectively (13.8% vs. 11.7%, P=0.012; 12.0% vs. 6.8%, P=0.000).</p><p><b>CONCLUSIONS</b>The prevalence of MS in Beijing population is high. The individuals with MS have a higher risk for other metabolic disorders and cardiovascular changes.</p>