Association Between Body Mass Index and Cognitive Function in Mild Cognitive Impairment Regardless of APOE ε4 Status

Background@#and Purpose: In this study we aimed to find the association between neuropsychological performance and body mass index (BMI) in patients with mild cognitive impairment (MCI). In addition, we investigated the effects of the apolipoprotein E (APOE) genotype in the relationship between the BMI and cognition in MCI. @*Methods@#We enrolled a cohort of 3,038 subjects with MCI aged 65–90 from the Clinical Research Center for Dementia of South Korea and a dementia cohort of the Ewha Womans University Mokdong Hospital. MCI patients were classified into three subgroups according to the Asian standard of BMI. We compared cognitive performances between groups by one-way analysis of variance. To investigate the effects of the APOE genotype, we used multivariate linear regression models after adjusting for possible confounders. @*Results@#Even though normal BMI groups were younger, had more females, and had less comorbidities, the higher BMI groups had better cognitive functions. Among subjects with APOE ε4 carriers, there was a positive relationship between the BMI and the memory task alone. @*Conclusions@#Our findings suggested that higher BMI in patients with MCI were associated with better cognitive performance. The effects of the APOE ε4 genotype in the associations between BMI and cognition were distinguishing. Therefore, according to physical status, APOE ε4 genotype-specific strategies in the assessments and treatments may be necessary in elderly patients with MCI.

18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment

Purpose@#Neuroinflammation is considered an important pathway associated with several diseases that result in cognitive decline. 18F-THK5351 positron emission tomography (PET) signals might indicate the presence of neuroinflammation, as well as Alzheimer’s disease-type tau aggregates. β-amyloid (Aβ)-negative (Aβ–) amnestic mild cognitive impairment (aMCI) may be associated with non-Alzheimer’s disease pathophysiology. Accordingly, we investigated associations between 18F-THK5351 PET positivity and cognitive decline among Aβ– aMCI patients. @*Materials and Methods@#The present study included 25 amyloid PET negative aMCI patients who underwent a minimum of two follow-up neuropsychological evaluations, including clinical dementia rating-sum of boxes (CDR-SOB). The patients were classified into two groups: 18F-THK5351-positive and -negative groups. The present study used a linear mixed effects model to estimate the effects of 18F-THK5351 PET positivity on cognitive prognosis among Aβ– aMCI patients. @*Results@#Among the 25 Aβ– aMCI patients, 10 (40.0%) were 18F-THK5351 positive. The patients in the 18F-THK5351-positive group were older than those in the 18F-THK5351-negative group (77.4±2.2 years vs. 70.0±5.5 years; p<0.001). There was no difference between the two groups with regard to the proportion of apolipoprotein E ε4 carriers. Interestingly, however, the CDR-SOB scores of the 18F-THK5351-positive group deteriorated at a faster rate than those of the 18F-THK5351-negative group (B=0.003, p=0.033). @*Conclusion@#The results of the present study suggest that increased 18F-THK5351 uptake might be a useful predictor of poor prognosis among Aβ– aMCI patients, which might be associated with increased neuroinflammation (ClinicalTrials.gov NCT02656498).

Psychological characteristics of premedical students in the situation of COVID-19 and educational effect of self reflection meditation / 의료커뮤니케이션

Background@#: In the situation of the national crisis caused by Covid-19, healthcare providers face leadership challenges and professional composure for the benefit of the community. This article aims to find out that self-reflection meditation class for premedical students improves medical leadership and resilience needed for healthcare providers. @*Methods@#: The sample was comprised of 109 premedical students at Pusan National University. We lectured ‘Physicians and leadership’ class focused on self-reflection and meditation for six weeks. We surveyed stress factors, self-reflection, self-esteem, and expectations for life before the class and asked about course satisfaction and changes after the class. A total of 109 questionnaires were retrieved to analyze the data and derive the results of the study. @*Results@#: In the questionnaires about stress factors and self-reflections, grades and exams and questions related to expectations for life recorded the highest average, and negative thinking about self-esteem has the lowest score. In the questionnaire, which asked students to describe their feelings and changes through meditation, most students answered that they could learn to empty negative feelings and be emotionally calm and stable. These were also found in the reflection note analysis. Students experienced ‘self-understanding through deep reflection’ and ‘resolve vague anxiety and fear’ through meditation. This also leads to increase self-awareness and self-satisfaction. @*Conclusion@#: Self-reflection meditation class improved emotional and psychological stability for students and fostered self-leadership to drive their lives in the direction they want. This facilitates interpersonal relationships, leadership, and resilience needed as a healthcare provider.

Effect of Medical Communication Curriculum with Empowering Self Reflection Activities for Pre-medical Students / 의료커뮤니케이션

Background@#: Medical communication is important skill which doctors need to acquire in order to satisfy the patients and improve results of treatment. The purpose of this article is to find out the effects of medical communication curriculum with empowering self reflection activities for pre-medical students. @*Methods@#: For the purpose, the six steps of concept mapping process proposed by Trochim were carried out. Using 52 statements to question number 1, 38 statements to question number 2, group similarity matrix were completed, which was further analyzed by SPSS using multidimensional scaling technique. And we conducted hierarchical cluster analysis(HCA) that helps to determine the number of cluster of the statements. @*Results@#: The HCA resulted in six clusters as the effects of medical communication curriculum with empowering self reflection activities conducted for 15 weeks. The six clusters as the effects of self reflection activities were labelled as emotional comfort, positive thinking, future life, the improvement of self-understanding, interpersonal relationships and medical communication. The six clusters as the effects of communication curriculum were labelled as empathic attitude, medical communication skill, patient centered care, expansion to social relationships, to social services and influence on future view. @*Conclusion@#: Medical communication curriculum with empowering self reflection activities was effective in improving the communication skill and inner growth for premedical students.

The Effect of Seoul Dementia Healing Design Project on Cognition and Social Engagement

Background@#and Purpose: Rapid population aging and an increase in the demented elderly became major social concerns in South Korea. Environmental design is increasingly recognized as an important aid for long-term care of patients with dementia as well as pharmacotherapy. We did a pilot study to investigate the effect of the Seoul Dementia Healing Design Project In-House Design (S-DHDP-IHD) in improving the quality of life of the cognitively impaired patients and of the S-DHDP Environmental Design (S-DHDP-ED) in increasing daily outdoor activities for cognitively impaired individuals and not cognitively impaired (NCI) elderly residents. @*Methods@#We applied the S-DHDP-IHD to 2 households of patients with mild cognitive impairment (MCI) and early-stage vascular dementia (VD). We assessed the effectiveness of intervention by surveys and video recordings of daily tasks. Additionally, we applied the S-DHDP-ED to 5 community facilities and randomly selected 287 residents over 65 years old (32 dementia caregivers and 255 NCI elderly) to participate in surveys. @*Results@#S-DHDP-IHD intervention showed improved instrumental activities in MCI patient and early-stage VD patient. Also, the satisfaction with an intervened home environment was increased. Following S-DHDP-ED intervention, non-demented residents engaged in more outdoor and social activities. They were also satisfied with the function and design of the installed facilities. @*Conclusions@#S-DHDP encompassing both home and environmental improvements was effective in readapting cognitively impaired individuals and could achieve a customized, holistic approach to dementia caregiving by means of the improved design.

The Effect of Seoul Dementia Healing Design Project on Cognition and Social Engagement

Background@#and Purpose: Rapid population aging and an increase in the demented elderly became major social concerns in South Korea. Environmental design is increasingly recognized as an important aid for long-term care of patients with dementia as well as pharmacotherapy. We did a pilot study to investigate the effect of the Seoul Dementia Healing Design Project In-House Design (S-DHDP-IHD) in improving the quality of life of the cognitively impaired patients and of the S-DHDP Environmental Design (S-DHDP-ED) in increasing daily outdoor activities for cognitively impaired individuals and not cognitively impaired (NCI) elderly residents. @*Methods@#We applied the S-DHDP-IHD to 2 households of patients with mild cognitive impairment (MCI) and early-stage vascular dementia (VD). We assessed the effectiveness of intervention by surveys and video recordings of daily tasks. Additionally, we applied the S-DHDP-ED to 5 community facilities and randomly selected 287 residents over 65 years old (32 dementia caregivers and 255 NCI elderly) to participate in surveys. @*Results@#S-DHDP-IHD intervention showed improved instrumental activities in MCI patient and early-stage VD patient. Also, the satisfaction with an intervened home environment was increased. Following S-DHDP-ED intervention, non-demented residents engaged in more outdoor and social activities. They were also satisfied with the function and design of the installed facilities. @*Conclusions@#S-DHDP encompassing both home and environmental improvements was effective in readapting cognitively impaired individuals and could achieve a customized, holistic approach to dementia caregiving by means of the improved design.

Four-Week, Home-Based, Robot Cognitive Intervention for Patients with Mild Cognitive Impairment: a Pilot Randomized Controlled Trial

Background@#and Purpose: Previous studies suggest that cognitive intervention can mitigate the development of dementia in patients with mild cognitive impairment (MCI). However, the previous cognitive intervention was mostly provided as a group session, in which MCI patients sometimes had difficulty in regularly attending sessions or were reluctant to participate in group-based classes. Additionally, experienced instructors for traditional cognitive intervention may be unavailable in some chronic-care facilities or community centers. Considering these reasons, we have developed 5 programs for home-based cognitive intervention using a personal robot for MCI patients. In this preliminary study, we aimed to demonstrate the effects of our newly developed home-based cognitive intervention with robots on cognitive function in MCI patients. @*Methods@#We conducted a single-blind randomized controlled trial enrolling 46 MCI patients. Participants were randomized into 2 groups: the robot cognitive intervention (robot) (n=24) group and without cognitive intervention (control) (n=22) group. The interventions comprised 60-min sessions per day for 4 weeks. The primary outcome was the change in cognitive function measured using the Cambridge Neuropsychological Test Automated Battery. @*Results@#There were no significant baseline demographic or clinical differences between the robot and control groups. After the 4-week cognitive intervention, the robot group showed greater improvement in working memory than did the control group. @*Conclusions@#Our home-based cognitive intervention with a personal robot improved the working memory in MCI patients. Further studies with larger samples and longer study periods are required to demonstrate the effects of these programs in other cognitive domains in MCI patients.

The Effect of Self Reflection Meditation Program on the Job Stress and Psychosocial Health of Government Staffs / 의료커뮤니케이션

BACKGROUND: The government staffs studied in this research has been easily exposed to excessive job stress, which can lead to a variety of psychosocial problems and poor quality of life. In this study, we examined the effect of the self reflection meditation program on the psychosocial health and stress responses of government staffs, to suggest the intervention program improving psychosocial health and quality of life in government staffs.METHODS: In this study, we measured the conditions of 36 local government staffs based on self reflection scale, psychosocial health and stress score before and after implementing the short-term intensive meditation program.RESULTS: The results showed that there were significant increase in social role performance and self confidence(p=.003), general health and vitality(p=.019) and significant decrease in stress(p=.010). This change was prominently showed in administrative officer and depression and anxiety(p=.034) also significantly decreased after program.CONCLUSION: Self reflection meditation program was effective in improving the psychosocial health and physical health of government staffs. Therefore, self reflection meditation program could be proposed as program for stress management and promotion of quality of life in government staff.

Spontaneous Repetitive Constriction and Dilatation of a Unilateral Pupil in a Brain Death Patient

In brain death state, bilateral pupil light reflexes are disappeared, and pupils are fixed with dilated. However, spontaneous movements such as ocular microtremor or bilateral cyclical constriction-dilatation of pupils have been rarely reported in brain death patients. We present a brain death patient whose right pupil displayed spontaneously repetitive constriction and dilatation regardless of external stimuli such as light and pain. Early recognition of this phenomenon may prohibit the delay in the diagnosis of brain death and organ transplantation.

A Patient with Corpus Callosum Infarction Accompanying Infective Endocarditis

No abstract available.

A Patient with Cerebral Infarction and Renal Infarction Accompanying Complex Aortic Plaque of Descending Thoracic Aorta

No abstract available.

High Dietary Glycemic Load is Associated with Poor Functional Outcome in Patients with Acute Cerebral Infarction

BACKGROUND AND PURPOSE: Elevated postprandial blood glucose is a critical risk factor for stroke. The dietary glycemic load (GL) and glycemic index (GI) are frequently used as markers of the postprandial blood glucose response to estimate the overall glycemic effect of diets. We hypothesized that high dietary GL, GI, or total carbohydrate intake is associated with a poor functional outcome in patients with acute ischemic stroke. METHODS: We prospectively included 263 first-ever ischemic stroke patients who completed a semiquantitative food-frequency questionnaire. The dietary GL, GI, and total carbohydrate intake were investigated by examining the average frequency of intake during the previous year based on reference amounts for various food items. Poor functional outcome was defined as a score on the modified Rankin Scale (mRS) of ≥3 at 3 months after stroke. RESULTS: The patients were aged 65.4±11.7 years (mean±standard deviation), and 58.2% of them were male. A multivariate analysis adjusted for age, sex, marital status, prestroke mRS score, diabetes mellitus, hyperlipidemia, body mass index, triglycerides, low-density lipoprotein, hemoglobin A1c, stroke classification, and National Institutes of Health Stroke Scale score, early neurological deterioration, and high-grade white-matter hyperintensities revealed that the dietary GL and total carbohydrate intake were associated with a poor functional outcome, with odds ratios for the top quartile relative to the bottom quartile of 28.93 (95% confidence interval=2.82–296.04) and 36.84 (95% confidence interval=2.99–453.42), respectively (p for trend=0.002 and 0.002, respectively). In contrast, high dietary GI was not associated with a poor functional outcome (p for trend=0.481). CONCLUSIONS: Increased dietary GL and carbohydrate intake were associated with a poor short-term functional outcome after an acute ischemic stroke.

Medical Professionalism and Self-Reflection in Medical Education / 의학교육논단

Recently, unprofessional behavior by physicians and misconduct by medical students have led to increased public concern over medical professionalism. Many studies have been conducted to explore strategies that reinforce professionalism education and prevent misconduct in medical students. However, most studies focused on defining the medical professionalism and its conceptual components. In this study, we conducted a conceptual analysis based on the literature review to categorize issues of unprofessional behavior, and identified doctors' indifference to self and others as the reason for the unprofessional behavior. In this regard, self-reflection provides a practical tool to overcome such indifference. We suggest ‘education and evaluation based on self-reflection and reflective practices’ as the effective strategies to enhance the professionalism in medical students.

Isolated Focal Cortical Infarction in a Patient with Churg-Strauss Syndrome

No abstract available.

Ischemic Stroke with Extracranial Internal Carotid Artery Occlusion in Essential Thrombocythemia with JAK-2 Mutation

In essential thrombocythemia (ET), cerebral infarction with large cerebral artery occlusion has rarely been reported. A 53-year-old male was admitted with left sided weakness. Brain magnetic resonance images revealed right internal carotid artery (ICA) territory infarction and proximal ICA occlusion. The blood laboratory examination demonstrated continuously increased platelet count (above 617,000/µL). Increased megakaroycytes and JAK2 V617F mutation were confirmed in the bone marrow biopsy. We should consider the possibility of ET in patient with large artery thrombosis and thrombocythemia.

The Effect of Obesity-Related Quality of Life on selecting a Goal for Weight Management in Overweight and Obese Patients / 대한지역사회영양학회지

OBJECTIVES: Obesity is known to influence physical and mental health as well as the general quality of life. The aim of this study was to evaluate the effect of obesity related quality of life on selecting a goal for weight management in overweight and obese female patients. METHODS: A total of 140 overweight or obese (Body mass index 23 kg/m2) female outpatients aged > or = 20 and < or = 60 years from one clinic participated in this study. Patients' desired weight (goal weight, ideal weight, satisfactory weight, acceptable weight and disappointed weight) and obesity related quality of life measures were evaluated. Univariate and multivariate analysis were performed to evaluate the effect of obesity related quality of life on goal weight reduction (%) and goal body mass index (BMI). RESULTS: Mean BMI of overweight group, mild obesity group and severe obesity group were 62.0 +/- 4.8 kg, 68.5 +/- 5.5 kg and 83.5 +/- 9.6 kg, respectively. Mean weight loss expectations of the three groups were 16.4 +/- 4.7%, 19.5 +/- 5.3% and 30.2 +/- 6.8%, respectively and goal weight was significantly different among the three groups. Severe obesity group had a lower total quality of life score including physical, work-related, daily living domains than overweight or mild obesity groups. In univariate and multivariate regression analysis, psychosocial domain of quality of life had an effect on goal weight reduction (%) and goal BMI. CONCLUSIONS: The results of this study demonstrated that the obese patients with poorer quality of life and psychosocial health tended to choose higher goal weight reduction and lower goal BMI.

Medical students' empathy and its effect on the physicianpatient relationship / 한국의학교육

PURPOSE: Recent studies have emphasized the importance of empathy in the physician-patient relationship (PPR). The purpose of this study was to examine the association between empathy scores, as measured by the student version of the Jefferson Scale of Empathy, Korean edition (JSE-S-K), and PPR scores on the clinical performance examination (CPX). METHODS: The sample comprised 104 third-year medical students. Prior to undertaking 12 cases on the CPX, the students completed the JSE-S-K and Myers-Briggs Type Indicator. We analyzed the differences in empathy and PPR scores according to their sociodemographic characteristics and personality types and verified the link between empathy and PPR scores by stepwise multiple linear regression analysis. RESULTS: PPR scores were positively associated with total JSE-S-K scores (r=0.232, p<0.05) and its affective domain scores (r=0.229, p<0.05). Education program (undergraduate or graduate entry) and empathy score were the best predictors of PPR score (R2=0.153). CONCLUSION: The positive association between empathy and PPR scores suggests that empathy is an important factor that influences the PPR.

Patient-Centeredness of Medical Students during a Real Patient Encounter and a Standardized Patient Encounter on the Clinical Performance Examination / 한국의학교육

PURPOSE: Patient-centered care is one of the most important factors of high-quality medical care. Medical educators have been increasingly interested in education for patient-centered care. This study was conducted to guide such education by assessing the patient-centeredness of medical students in a real patient encounter and a standardized patient encounter on the clinical performance examination (CPX). METHODS: During the first semester of 2010 and 2011, fourth-year medical students in a clinical clerkship interviewed outpatients who visited the Department of Family Medicine. The interviews were videotaped, 25 of which were selected for study. We searched the 25 students' CPX videotapes that were recorded in the same year for comparison. The patient-centeredness of the students was assessed by measure of patient-centered communication (MPCC). RESULTS: The inter-rater reliability of the MPCC was 0.89 when measuring real patient encounters. MPCC scores of 25 students were very low for both real patients (mean, 28.8; range, 8.2~53.1) and for standardized patients (mean, 27.5; range, 8.2~52.7), and there was no significant difference between two groups. The component 1 MPCC scores were significantly higher for real patient encounters compared with those of CPX encounters (0.28 vs 0.18, p=0.0001). The component 2, 3 MPCC scores of two groups were not different each other. CONCLUSION: Medical educators must emphasize the importance of exploring a patient's illness and social background and involving them in making a diagnosis and treatment plan for patient-centered care. They should give students more opportunities to interview real patients and diversify scenarios for standardized patients.

Validity and Reliability of Korean Version of International Physical Activity Questionnaire Short Form in the Elderly / 가정의학회지

BACKGROUND: Estimation of physical activity contributes to early screening and prevention of decrease in body function. This study was conducted to examine the reliability and validity of the International Physical Activity Questionnaire (IPAQ) short form in elderly people. METHODS: A total of 55 outpatients of 65 years old or older participated in this study. Physical activity over the last seven days was recorded on the IPAQ short form. Responses were converted to metabolic equivalent task minutes per week. The IPAQ short form was validated against accelerometer measurements as a gold standard. The test-retest method was performed over a two-week interval to examine the reliability of the IPAQ. RESULTS: The more physically active by the IPAQ short form, the higher the measured value of the accelerometer (P < 0.001). Pearson's correlation coefficient was 0.43 for the correlation between the results of two measurements. Spearman Rho coefficients and Kappa values of test-retest reliability in five elements (vigorous days, vigorous minutes, moderate days, moderate minutes, and walk days) were 0.299-0.605 and 0.307-0.418, respectively. CONCLUSION: The validity of the IPAQ short form was proven, but the reliability was found to be low. Nevertheless, IPAQ short form seems worthwhile tool for the measurement of physical activity levels, concerning daily variation in physical activity of the elderly.

The Association between Symptoms of Autonomic Neuropathy and the Heart Rate Variability in Diabetics / 가정의학회지

BACKGROUND: There are few tools to detect the diabetic autonomic neuropathy at an earlier stage. This study was conducted to investigate the association between symptoms of autonomic neuropathy and the heart rate variability (HRV) in diabetics. METHODS: Study subjects consisted of 50 diabetic patients and 30 outpatient hospital control patients at a university family medicine department. The patients completed a Korean version of composite autonomic symptom scale (COMPASS). Electrocardiography was recorded in the supine position, on standing, and during deep breathing, for 5 minutes each. HRV of frequency domain was calculated by power spectral analysis. RESULTS: The COMPASS score was higher in female diabetic patients compared with that in controls. Among 50 diabetic patients, the total COMPASS score correlated positively with normalized low frequency (LF) score (normalized units, n.u.) (r = 0.62, P < 0 .001) and low frequency/high frequency (LF/HF) (r = 0.77, P < 0.001), negatively with normalized HF score (n.u.) (r = -0.59, P < 0.001) and RMSSD (square root of the mean of the sum of the square of differences between adjacent NN interval; r = -0.33, P = 0.031). The decrease in LF (n.u) and the increase in HF (n.u) by deep breathing from the supine position were higher in diabetic patients compared with those in controls. The increase in LF (n.u) and the decrease in HF (n.u) by standing from the supine position were lower in diabetic patients compared with those in controls. CONCLUSION: The COMPASS score correlated with some component score of the HRV in diabetics. The HRV may be used as a tool to detect diabetic autonomic neuropathy by augmentation with position change.