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1.
Annals of Saudi Medicine. 2010; 30 (3): 236-238
em Inglês | IMEMR | ID: emr-98768

RESUMO

Differences in the histological manifestation of synchronous lung cancers are rare. Synchronous multiple primary lung cancers [SMPLC] are associated with long-term tobacco use, which could independently lead to mutations in the p53 and K-ras genes. We present the case of an 82-year-old man who smoked 30 cigarettes daily for the past 60 years. CT of the chest showed a right upper lobe mass. Bronchoscopy revealed an intra-lumen nodular lesion in the right lower lobe bronchus. The diagnoses of small cell lung carcinoma [SCLC] of the right upper lobe and non-small cell lung carcinoma [NSCLC] of the right lower lobe were confirmed by the morphologic features and the detected immunoreactivity. Immunohistochemical analyses showed a strong positive reaction for p53 in samples of the SCLC and NSCLC. The cancers had a different phenotype, but similar genetic abnormalities may have developed due to the carcinogens in the cigarettes


Assuntos
Humanos , Masculino , Idoso , Fumar/efeitos adversos , Carcinoma Pulmonar de Células não Pequenas/diagnóstico , Carcinoma de Pequenas Células do Pulmão/diagnóstico
2.
Korean Journal of Radiology ; : 93-96, 2009.
Artigo em Inglês | WPRIM | ID: wpr-20099

RESUMO

The radiological appearance of diffuse discrete pulmonary nodules associated with cryptogenic organizing pneumonia (COP) has been rarely described. We describe a case of COP in 49-year-old woman with acute myeloid leukemia who developed diffuse pulmonary nodules during the second course of induction chemotherapy. The clinical status of the patient and imaging findings suggested the presence of a pulmonary metastasis or infectious disease. A video-assisted thoracoscopic lung biopsy resulted in the unexpected diagnosis of COP as an isolated entity. Steroid therapy led to dramatic improvement of the clinical symptoms and the pulmonary lesions.


Assuntos
Feminino , Humanos , Pessoa de Meia-Idade , Pneumonia em Organização Criptogênica/complicações , Diagnóstico Diferencial , Leucemia Mieloide Aguda/complicações , Pulmão/diagnóstico por imagem , Neoplasias Pulmonares/diagnóstico por imagem , Nódulos Pulmonares Múltiplos/complicações
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