Molecular mechanism of a Matijin-su derivative for inhibiting proliferation, invasion and migration of prostate cancer cells / 中国药理学通报

Aim To investigate the effects of HXL130 on the proliferation, invasion and migration of prostate cancer PC3 cells and its molecular mechanism. Methods MTT assay was used to detect the effect of HXL130 on the proliferation of prostate cancer PC3 cells. Hoechst 33258 staining and flow cytometry were used to detect the effects on apoptosis and cell cycle of cancer cells. Transwell was used to detect the effects of compounds on the invasion and migration of cancer cells. Proteomic sequencing was employed to detect differentially expressed proteins (DEPs) induced by compound treatment of cancer cells. Bioinformatics was used to analyze the functions of DEPs and the related signaling pathways regulated by DEPs, and Western blot was used to verify the result. Results The survival rate of PC3 cells decreased with the increase of HXL130 concentration and treatment time. HXL130 could significantly induce cell apoptosis and block G

Alveolar echinococcosis metastatic to the brain: a case report / 中国血吸虫病防治杂志

This paper reports a case with alveolar echinococcosis metastatic to the brain. This case underwent 10-year antiechinococcosis treatment and operations of the liver, right kidney and brain. Following multiple operations and oral administration of albendazole, the case still had recurrence and distant metastasis of hepatic echinococcosis. It is suggested that early prevention, early diagnosis, early regular treatment and surgical radical treatment are critical to the treatment of alveolar echinococcosis.

Primary cystic echinococcosis in the left femur: a case report / 中国血吸虫病防治杂志

This article reported a case with primary cystic echinococcosis in the left femur.

Advances in CT image characteristics for predicting hematoma enlargement in spontaneous intracerebral hemorrhage / 医学研究生学报

Spontaneous intracerebral hemorrhage (sICH) accounts for approximately 10% to 15% of stroke patients. The key factor affecting the prognosis of sICH is whether the initial hematoma volume and hematoma enlarge. Current research indicates that sICH is a common disease caused by rupture of small blood vessels with poor prognosis. More than 30% of patients have persistent bleeding after the first onset, indicating that the disease is a dynamic process. This persistent bleeding, also known as hematoma expansion (HE), is an independent predictor of neurological deterioration and poor prognosis. This article reviews the research progress of CT image features and specific imaging findings on CTA in predicting HE in patients with sICH.