Research Advances of RAD51AP1 in Tumor Progression and Drug Resistance / 中国肺癌杂志

The genomic instability may lead to an initiation of cancer in many organisms. Homologous recombination repair (HRR) is vital in maintaining cellular genomic stability. RAD51 associated protein 1 (RAD51AP1), which plays a crucial role in HRR and primarily participates in forming D-loop, was reported as an essential protein for maintaining cellular genomic stability. However, recent studies showed that RAD51AP1 was significantly overexpressed in various cancer types and correlated with poor prognosis. These results suggested that RAD51AP1 may play a significant pro-cancer effect in multiple cancers. The underlying mechanism is still unclear. Cancer stemness-maintaining effects of RAD51AP1 might be considered as the most reliable mechanism. Meanwhile, RAD51AP1 also promoted resistance to radiation therapy and chemotherapy in many cancers. Thus, researches focused on RAD51AP1, and its regulatory molecules may provide new targets for overcoming cancer progression and treatment resistance. Here, we reviewed the latest research on RAD51AP1 in cancers and summarized its differential expression and prognostic implications. In this review, we also outlined the potential mechanisms of its pro-cancer and drug resistance-promoting effects to provide several potential directions for further research.
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Analysis of the utilization of antibacterial drugs in 100 cases of old community-acquired pneumonia with chronic obstructive pulmonary disease / 中国基层医药

Objective To investigate the utilization of antibacterial drugs in the old community-acquired pneumonia (CAP) with chronic obstructive pulmonary disease(COPD) in our hospital.To analyze the rational application of antibacterial drugs,thus to provide a powerful reference for clinical diagnosis and treatment.Methods From June 2011 to June 2013,100 patients with COPD and CAP were selected in Xiaolan People's Hospital.The average age was (76.95 ±6.57) years old,including 62 males and 38 females.The utilization of antibacterial drugs was investigated by retrospective study in the patients.Results In the course of treatment,the rate of using the antibacterial drugs in 100 patients was 100％,concerning 13 varieties of 5 major categories,including β-lactam (including β-lactam/β-lactamase inhibitors),quinolones,carbapenems,macrolides,aminoglycosides.The largest frequency was piperacillin/sulbactam,up to 92.Ceftezole,cefotian and azithromycin were less than 0.9 for DUI in DDDS ordering 10 drugs,it showed that the frequency was insufficient or the dosage was too small.For example,insufficient frequency of cephalosporin once a day and small dosage of azithromycin 0.25g once a day.Combination with two kinds of antimicrobial drugs was common,it was relatively rational between the combination of drugs,usually cephalosporins + quinolones,β-lactam/β-lactamase inhibitors + quinolones,β-lactam/β-lactamase inhibitors + macrolides.Conclusion The etiology of 100 elderly patients with COPD and CAP in our hospital is mainly Gram-negative bacteria.The anti-infection treatment is mainly cefdiazine and piperacillin/sulbactam,and the combined drug was mainly quinolones.The drug regimen and treatment course are reasonable,there is a high prognosis in the patients.

Analysis of the utilization of antibacterial drugs in 100 cases of old community-acquired pneumonia with chronic obstructive pulmonary disease / 中国基层医药

Objective@#To investigate the utilization of antibacterial drugs in the old community-acquired pneumonia (CAP) with chronic obstructive pulmonary disease(COPD) in our hospital.To analyze the rational application of antibacterial drugs, thus to provide a powerful reference for clinical diagnosis and treatment.@*Methods@#From June 2011 to June 2013, 100 patients with COPD and CAP were selected in Xiaolan People's Hospital.The average age was (76.95±6.57) years old, including 62 males and 38 females.The utilization of antibacterial drugs was investigated by retrospective study in the patients.@*Results@#In the course of treatment, the rate of using the antibacterial drugs in 100 patients was 100%, concerning 13 varieties of 5 major categories, including β-lactam (including β-lactam/β-lactamase inhibitors), quinolones, carbapenems, macrolides, aminoglycosides.The largest frequency was piperacillin/sulbactam, up to 92.Ceftezole, cefotian and azithromycin were less than 0.9 for DUI in DDDS ordering 10 drugs, it showed that the frequency was insufficient or the dosage was too small.For example, insufficient frequency of cephalosporin once a day and small dosage of azithromycin 0.25g once a day.Combination with two kinds of antimicrobial drugs was common, it was relatively rational between the combination of drugs, usually cephalosporins+ quinolones, β-lactam/β-lactamase inhibitors+ quinolones, β-lactam/β-lactamase inhibitors+ macrolides.@*Conclusion@#The etiology of 100 elderly patients with COPD and CAP in our hospital is mainly Gram-negative bacteria.The anti-infection treatment is mainly cefdiazine and piperacillin/sulbactam, and the combined drug was mainly quinolones.The drug regimen and treatment course are reasonable, there is a high prognosis in the patients.