Study on the effect of functional movement on the recurrence of patients with ankylosing spondylitis after treat-to-target therapy / 中华风湿病学杂志

Objective:To investigate the effect of functional movement assessment on the recurrence of patients with ankylosing spondylitis (AS) after treat-to-target therapy.Methods:The clinical data of 61 patients with AS in Chengdu were collected including clinical symptoms and AS disease activity (ASDAS). After 24 weeks adalimumab treatment, motor function score of AS patients(ASDAS<1.3) was assessed by functional movement screen (FMS), then adalimumab was discontinued and the rest of the concurrent drugs were continued until the disease relapse or up to 1 year. The data of the two groups were compared using t-test analysis and Cox proportionate hazard model. Results:① The recurrence rate of patients with AS after treat-to-target therapy within 1 year follow-up was 57.4%; ② The recurrence group was younger [(27±7) vs (31±6), t=5.96, P=0.02], the ASADAS value was at the high end when adalimumab was withdrawal [(1.29±0.07) vs (0.87±0.16), t=177.31, P<0.01], and the FMS value was lower after treat-to-target [(12.9±2.7) vs (16.2±1.9), t=29.23, P<0.01], The time to reaching the treatment target was longer [(2.9±1.2) month vs (1.7±0.6) month, t=19.89, P<0.01] than the stable group; ③ The cut-off value of the FMS test of AS patients after treat-to-target therapy was 14.25 (sensitivity was 84.6%, specificity was 80%) . The time to treat-to-target was a risk factor for recurrence ( RR=2.285, P<0.05), and the FMS value after treat-to-target was a protective factor ( RR=0.625, P<0.05). Conclusion:After discontinuing the adalimumab, about half of the patients relapse. The time reaching the treatment target and the FMS value after treat-to-target therapy are the risk factors for disease recurrence.

Biometry of width between labial transitional line angles in anterior teeth:an observational study

PURPOSE@#The maximum width between the mesial and distal labial transitional line angles, described as “esthetic width” herein, could significantly influence the visual perception of the teeth and smile. This study aimed to conduct biometric research on esthetic width and to explore whether regular distribution exists in the esthetic width of human teeth. @*MATERIALS AND METHODS@#A total of 4,264 maxillary and mandibular anterior teeth were measured using the Geomagic studio software program. The proportions of maxillary to mandibular homonymous teeth and proportions between the adjacent teeth were calculated. Bilateral symmetry and the correlation between the esthetic and mesiodistal widths were both accounted for during the measurement procedures. @*RESULTS@#The mean esthetic widths were 6.773 ± 0.518 mm and 4.329 ± 0.331 mm for maxillary and mandibular central incisors, respectively, 5.451 ± 0.487 mm and 5.008 ± 0.351 mm for maxillary and mandibular lateral incisors, respectively, and 3.340 ± 0.353 mm and 5.958 ± 0.415 mm for maxillary and mandibular canines, respectively. Except for the mandibular canines, no significant difference in esthetic width was found among homonymous teeth from the same jaw. A high linear correlation was found between the esthetic and mesiodistal widths of the same tooth, except for the maxillary canines. Esthetic width proportions among different tooth categories showed some regular patterns, which were similar to those of the mesiodistal width. @*CONCLUSION@#Esthetic width is regularly distributed among the teeth in the Chinese population. This could provide an important reference for anterior dental restorations and dimension recovery in esthetic reconstruction of anterior teeth.

Evaluation of core muscle groups in ankylosing spondylitis based on DAVID spinal biomechanics training system / 中华风湿病学杂志

Objective To evaluate and describe the changes of core muscle groups based on DAVID spine biomechanics training system in ankylosing spondylitis (AS) patients.Methods The clinical data of 100 patients of AS and 31 healthy controls were collected.Clinical symptoms,Bath ankylosing spondylitis disease activity index (BASDAI),Bath ankylosing spondylitis function index (BASFI),Bath ankylosing spondylitis measurement index (BASMI),ankylosing spondylitis disease activity (ASDAS),and simultaneous detection of DAVID spine biomechanics training system,simple core muscle fitness test:Eight-grade abdominal bridge,PLANK exercise (fiat support),Abdominal static muscle endurance test,Back static muscle endurance test were compared using t-test analysis and spearman correlation analysis.Results ① Between AS and healthy male control o group,there were significant differences of spinal mobility in forward flexion,right rotation,left rotation (42±13 vs 48±1,52±14 vs 69±12,52±13 vs 58±11;all P values ＜0.05);and significant differences of spinal muscle strength in forward bending force,right rotation force,left rotation force,fight bending force (103±42 vs 146±17,87±34 vs 104±13,80±35 vs 101±13,161±55 vs 186±19;all P values ＜0.05),and significant differences in the left/right rotational force (1.17±0.21 vs 1.02±0.111,P＜0.05) of spine balance strength comparison.② Between AS and healthy controls of female group,there were differences in forward bending force (49±23 vs 77±10,P＜0.05) of spinal muscle strength;and significant differences in forward bending/backward extension strength,left and right rotation strength (0.32±0.11 vs 0.58±0.21,1.29±0.21 vs 1.03±0.11,all P values ＜0.05) of spine balance strength;③ In AS group,the spinal mobility was correlated with age (Rear extension r=-0.28,right flexion r=-0.268,left flexion r=-0.404,right rotation r=-0.367,left rotation r=-0.235;all P values ＜0.05),course of disease (Rear extension r=-0.354,forward flexion r=-0.283,right flexion r=-0.204,left flexion r=-0.284,right rotation r=-0.339,left rotation r=-0.23;all P values ＜0.05),body mass index (BMI) (Rear extension r=-0.23,forward flexion r=-0.288,right flexion r=-0.22,left flexion r=-0.201,right rotation r=-0.26,left rotation r=-0.29;all P values ＜0.05),sacroiliac joint stage(Rear extension r=-0.375,forward flexion r=-0.446,right flexion r=-0.331,left flexion r=-0.367,right rotation r=-0.368,left rotation r=-0.314;all P values ＜0.05) and BASDAI(Rear extension r=-0.381,forward flexion r=-0.374;all P values ＜0.05).Spinal muscle strength was correlated with gender (Posterior extensor force r=0.344,flexor force r=0.507,right rotation force r=0.376,left rotation force r=0.399,right flexion force r=0.433,left flexion force r=0.445;all P values ＜0.05);the left/right spine rotation strength was correlated with gender (r=0.271,P＜0.05).④ In the simple core muscle fitness test,eight-grade abdominal bridge was correlated with spinal muscle strength (Rear extension force r=0.234,right rotation r=0.290,left rotation r=0.219,right flexion r=0.35,left flexion r=0.327;all P values ＜0.05);PLANK exercise was correlated with spinal muscle strength (Rear extension force r=0.234,right rotation r=0.290,left rotation r=0.219,right flexion r=0.35,left flexion r=0.327;all P values ＜0.05);abdominal static muscle endurance test was correlated with forward flexion strength (r=0.341,P＜0.05);back static muscle endurance test was correlated with spinal mobility (Rear extension r=0.262,forward flexion r=0.23,right rotation r=0.455,left rotation r=0.426,right flexion r=0.387,left flexion r=0.46;all P values ＜0.05);correlated with spine strength (right flexion r=0.256,left flexion r=0.272;all P values ＜0.05).Conclusion Compared with healthy people,AS patients have decreased activity,strength and balance of spinal core muscle.There are significant decline in spinal mobility and muscle strength of male AS patients and muscle imbalance of female AS patients.Simple core muscle fitness test could be used in clinic to measure the changes of AS patients'core muscle group.

Evaluation of core muscle groups in ankylosing spondylitis based on DAVID spinal biomechanics training system / 中华风湿病学杂志

Objective@#To evaluate and describe the changes of core muscle groups based on DAVID spine biomechanics training system in ankylosing spondylitis (AS) patients.@*Methods@#The clinical data of 100 patients of AS and 31 healthy controls were collected. Clinical symptoms, Bath ankylosing spondylitis disease activity index (BASDAI), Bath ankylosing spondylitis function index (BASFI), Bath ankylosing spondylitis measurement index (BASMI), ankylosing spondylitis disease activity (ASDAS), and simultaneous detection of DAVID spine biomechanics training system, simple core muscle fitness test: Eight-grade abdominal bridge, PLANK exercise (flat support), Abdominal static muscle endurance test, Back static muscle endurance test were compared using t-test analysis and spearman correlation analysis.@*Results@#① Between AS and healthy male control o group, there were significant differences of spinal mobility in forward flexion, right rotation, left rotation (42±13 vs 48±1, 52±14 vs 69±12, 52±13 vs 58±11; all P values <0.05); and significant differences of spinal muscle strength in forward bending force, right rotation force, left rotation force, right bending force (103±42 vs 146±17, 87±34 vs 104±13, 80±35 vs 101±13, 161±55 vs 186±19; all P values <0.05), and significant differences in the left/right rotational force (1.17±0.21 vs 1.02±0.111, P<0.05) of spine balance strength comparison.② Between AS and healthy controls of female group, there were differences in forward bending force (49±23 vs 77±10, P<0.05) of spinal muscle strength; and significant differences in forward bending/backward extension strength, left and right rotation strength (0.32±0.11 vs 0.58±0.21, 1.29±0.21 vs1.03±0.11, all P values <0.05) of spine balance strength; ③ In AS group, the spinal mobility was correlated with age (Rear extension r=-0.28, right flexion r=-0.268, left flexion r=-0.404, right rotation r=-0.367, left rotation r=-0.235; all P values <0.05), course of disease (Rear extension r=-0.354, forward flexion r=-0.283, right flexion r=-0.204, left flexion r=-0.284, right rotation r=-0.339, left rotation r=-0.23; all P values <0.05), body mass index (BMI) (Rear extension r=-0.23, forward flexion r=-0.288, right flexion r=-0.22, left flexion r=-0.201, right rotation r=-0.26, left rotation r=-0.29; all P values <0.05), sacroiliac joint stage(Rear extension r=-0.375, forward flexion r=-0.446, right flexion r=-0.331, left flexion r=-0.367, right rotation r=-0.368, left rotation r=-0.314; all P values <0.05) and BASDAI (Rear extension r=-0.381, forward flexion r=-0.374; all P values <0.05). Spinal muscle strength was correlated with gender (Posterior extensor force r=0.344, flexor force r=0.507, right rotation force r=0.376, left rotation force r=0.399, right flexion force r=0.433, left flexion force r=0.445; all P values <0.05); the left/right spine rotation strength was correlated with gender (r=0.271, P<0.05). ④ In the simple core muscle fitness test, eight-grade abdominal bridge was correlated with spinal muscle strength (Rear extension force r=0.234, right rotation r=0.290, left rotation r=0.219, right flexion r=0.35, left flexion r=0.327; all P values <0.05); PLANK exercise was correlated with spinal muscle strength (Rear extension force r=0.234, right rotation r=0.290, left rotation r=0.219, right flexion r=0.35, left flexion r=0.327; all P values <0.05); abdominal static muscle endurance test was correlated with forward flexion strength (r=0.341, P<0.05); back static muscle endurance test was correlated with spinal mobility (Rear extension r=0.262, forward flexion r=0.23, right rotation r=0.455, left rotation r=0.426, right flexion r=0.387, left flexion r=0.46; all P values <0.05); correlated with spine strength (right flexion r=0.256, left flexion r=0.272; all P values <0.05).@*Conclusion@#Compared with healthy people, AS patients have decreased activity, strength and balance of spinal core muscle. There are significant decline in spinal mobility and muscle strength of male AS patients and muscle imbalance of female AS patients. Simple core muscle fitness test could be used in clinic to measure the changes of AS patients'core muscle group.

1H-MRS detection of metabolites in posterior cingulate gyrus of Parkinson disease with cognitive impairment patients / 中国医学影像技术

Objective To investigate the value of 1H-MRS technology combined with linear combination model (LCmodel) software in diagnosis of Parkinson disease (PD) cognitive impairment.Methods Thirty-five PD patients (PD group) and 22 matched healthy subjects (control group) were collected.Patients in PD group were divided into PDN and PDMCI subgroups according to whether having cognitive impairment or not.The concentration of metabolites of posterior cingulate gyrus (PCG)was applied with 1H-MRS technology combined with LCmodel software.The differences of metabolites were compared between the two groups,and the correlations between metabolites level and cognitive status were analyzed.Results The absolute concentrations of metabolites in PDN subgroup were not significantly different from those in control group (all P＞0.05).The absolute concentrations of total creatine (tCr),N-acetyl aspartate (NAA),myo-inositol (mI) and glycerophosphocholine+ phosphocholine (tCho) in PDMCI subgroup were lower than those in control group (all P＜0.05).The absolute concentration of tCr in PDMCI subgroup was lower than that in PDN subgroup (P＜0.05).There was positive correlation among the absolute concentration of tCr (r=0.444,P=0.01),glutathione (GSH;r=0.393,P=0.024) and MMSE scores,as well as among the absolute concentration of tCr (r=0.367,P=0.035),GSH (r=0.376,P=0.031),tCho (r=0.375,P=0.031) and MoCA scores.Conclusion 1 H-MRS technology combined with LCmodel software can quantitatively analyze the changes of metabolites in PCG,therefore being helpful to evaluating PD cognitive impairment.

MRI and DTI in evaluation on vascular cognitive impairment of rat models / 中国医学影像技术

Objective To explore the imaging indexes of early diagnosis of vascular cognitive impairment (VCI).Methods Totally 30 rats were collected and divided into model group (n=20) and control group (n=10).Modified 4-VO method was used to establish the VCI rat models.Morris water maze test was used to detect learning and memory abilities of rats.T2W and DTI scanning were performed in all rats 2 weeks,1 month,3 months and 5 months after operation,respectively.ROI was used to analyze the change of hippocampal volume and FA value.Voxel-based analysis (VBA) was used to analyze the change of FA value in all brain on DTI images.Then the rats were sacrificed,HE staining and Nissl staining of brain tissue slices were performed to observe the morphological changes.Results Compared with control group,the learning and memory ability of rats in model group decreased significantly.Compared with the control group,the hippocampal volume and FA value in model group decreased significantly at 3 months and 5 months after operation,respectively (all P＜0.05).FA in many brain areas reduced 1,3,5 months after operation in model group (all P＜0.05),and the decrease regions expanded with time going.Pyramidal cells in the hippocampal showed degeneration and nuclear condensation,and cytoplasmic Nissl bodies demonstrated reduction and disappearance gradually.Conclusion Changes of rat hippocampal volume and microscopic white matter may be helpful to early diagnosis of VCI.Decrease of FA value can be used as an indicator for early diagnosis and severity evaluation of VCI.

Study on Chaotic Detection Method of Pacemaker Contact-Less Power Supply / 生物医学工程学杂志

In order to improve the reliability of cardiac pacemaker contact-less power supply technology, this paper proposes a novel application of wireless feedback voltage stabilizing technology to adjust heart disease patients with inner power supply filter circuit output voltage and current control method, to keep the output voltage stability, and to ensure that the super capacitor and cardiac pacemaker to get a stable power supply. To implement the real-time accurate voltage control with considering the primary and secondary side inductance coupling coefficient changes, the change of the external power supply voltage and load, it is necessary to test thee real-time and accurate output voltage and current value after rectifying filtering. Therefore, based on the chaotic control theory, we adopted method of phase diagram on the basis of the quick observation after rectifying filtering, so that the method of voltage and current could improve the detection time of the circuit. The phase diagram of proposed control method can be divided into 8 segments, and we got 7 zero-extreme points. When these zero-extreme points are detected, according to extreme points of the zero instantaneous values, the corresponding average values of voltage and current were obtained. Simulation and experimental results showed that using the above method can shorten the response time to less than switch devices 1/2 switching cycles, thus validating the effectiveness and feasibility of the proposed detection algorithm.