RESUMO
As an essential micronutrient in mammals, iodine is involved in the synthesis of thyroid hormone and plays an important role in human life. Iodine itself has the characteristics of chemical elements, such as antioxidant, anti-inflammatory, and other effects. It plays a role in some free radical-related chronic diseases. Iodine also has anti-proliferation and pro-apoptotic effects on some tumor cells to inhibit tumor development. At present, many studies about iodine focus on its role in thyroid gland and its hormone. A little attention has been paid to the extrathyroidal action of iodine. Here we reviewed the role of iodine in extrathyroidal tissues and organs with iodine uptake capacity and its effect on metabolism.
RESUMO
Objective To investigate the correlations among homocysteine(Hcy)level,serum cystatin C (Cys-c)and diabetic peripheral neuropathy(DPN).Methods Two hundred and three diagnosed cases of type 2 diabetes were enrolled,including 123 DPN patients(DPN+)and 80 non-DPN(DPN-)patients.Levels of serum Hcy,Cys-c,high-sensitivity C-reactive protein(hs-CRP)and fiber fibrinogen(Fg)were detected.The above indi-cators and the baseline data such as sex,age,duration,BMI,WHR,HOMA-IR(CP),HOMA-islet(CP)were statistically analyzed. Results Hcy,Cys-c,and the duration of the DPN+ group were significantly higher than those in the DPN-group(P<0.05,respectively).HOMA-islet(CP)in the DPN-group was markedly higher than that in the DPN+group(P<0.01).The prevalence of DPN in the high level of Hcy group was much higher than that in the low and the normal level of Hcy group.Hcy was still significantly correlated with the Cys-c after taking the controlled procedure such as duration and fibrinogen. Conclusion High levels of Hcy and Cys-c are the criti-cal risk factors of DPN,collaborative determination of Hcy and Cys-c level might be of quitevaluable in early diag-nosis of DPN.