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Objective To evaluate potential protective effects of inhaled budesonide on bronchopulmonary dysplasia (BPD) in premature infants and its impact on the intelligence development at 1 year of age. Methods A total of 82 preterm infants admitted to the neonatal intensive care center from January 2017 to January 2018 were selected as research subjects. The enrolled subjects were divided into a study group (Budesonide) and a control group (saline) by random number table method, with 41 cases in each group. The incidence of BPD, mortality, hospitalization time, time of withdrawal and oxygenation, and complications were compared between the two groups. The patients were regularly followed up to 1 year old after discharge. The physical growth and Gesell intelligence development of the two groups were compared. Results The incidence of BPD in the study group was significantly lower than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in mortality between the two groups. The hospitalization time, weaning and oxygenation time, and 1-week re-intubation rate in the study group were significantly lower than those in the control group (P<0.05). There was no significant difference between the two groups in the incidence of adverse reactions and physical growth at 1 year old and Gesell intelligence evaluation. Conclusion Budesonide aerosol inhalation reduced the incidence of BPD in premature infants, shortened hospitalization and weaning time, and there were no near-term and long-term adverse reactions.
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Objective To investigate the effect of early intervention with education combined with treatment on developing intelligence of preterm infants. Methods Ninety seven preterm infants were assigned into the intervention group(n=49)and control group(n=48):Those in the former group were managed with early intervention by education combined with medical treatment and those in the latter were given routine preventive health service.The two groups were compared in terms of body length and weight at months 6,9 and 12 as well as the developmental quotient(DQ)with developmental screening test(DST). Result The scores on DQ in the intervention group were all significantly higher than those of the control at the three time points(all P<0.01).Conclusion The early intervention with education combined with treatment is effective for the early development of intelligence of preterm infants.
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Objective To investigate the role of dendritic cell (DC) subsets and T cell subpopulations expressing different intracellular cytokines in the pathogenesis of syphilis. Methods Flow cytometry was utilized to measure the frequencies of peripheral DC subsets and IFN-γ-, IL-2-, IL-4-, IL-10-expressing peripheral CD4+ and CD8+ T cell subpopulations in 20 patients with syphilis before and after therapy, and in 15 healthy human controls. Results The frequency of CD11c+ DC was significantly lower in pretreated patients than that in treated patients (P<0.01), but higher than that in the normal controls (P<0.05), and the same was true for the frequency of IFN-γ-expressing T cells, IL-2-expressing T cells, and IL-12-expressing T cells. By contrast, a decrease was noticed in the frequency of IL-4-expressing T cells and IL-10-expressing T cells in pretreated patients compared with that in the normal controls. Furthermore, in patients with syphilis, the frequency of CD11c+ and CD123+ DC was unrelated to the percentage of IFN-γ-expressing and IL-12- expressing T cells (both P>0.05). Conclusions IFN-γ, IL-2 and IL-12 may exert an immunoregnlatory effect in the eliminating of Treponema pallidum, whereas IL-4 and IL-10 may perform an imrnunoinhibitory effect.
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Objective:To prevent the drug-induced hearing impairment and deafness. Methods:To discuss the drug-induced hearing impairment from the drugs, mechanism, clinical symptom, other influencing factors and damaged therapeutics. Results:It is progressive for the drug-induced hearing impairment, and it may be discovered and treated in early stage. Conclusion:The preventive measures adopted and discovery in early stage of hearing impairment is the key to avoid the hearing loss.
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OBJECTIVE:To investigate the current situation and developing trend of the use of antidepressants in hospitals of Shanghai.METHODS:Using DDD as index,the data of antidepressants used in47hospitals in Shanghai during the period2000～2002were analyzed.RESULTS:The average annual increase rate of sum of money for antidepressants was15.33%.The sum of money for selective serotonin reuptake inhibitors(SSRIs)accounted for92.17%,and that of fluoxetine accounted for60.02%of the total antidepressants used.CONCLUSION:SSRIs occupied the antidepressants marketing predominance.
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OBJECTIVE:To evaluate the current situation and the trend of development of quinolones used in156hospitals of6cities in the Yangtze valley.METHODS:Quinolones used in156hospitals of6cities in the Yangtze valley were analyzed statistically in respect of the kind,consumption amount and DDDs etc..RESULTS:During the period of2000～2003,the annual increasing rate for consumption sum,DDDs and the defined daily cost of Quinolones used in156hospitals were22.08%,2.16%and19.50%respectively,with that of the higher defined daily cost increased faster,of which the annual increase rates in consumption sum and DDDs were up to33.22%and33.59%respectively,while the increasing percentage of oral quinolones was8.57%and-0.88%.Levofloxacin,which ranked the first in consumption,accounted for48.22%of total consumption and25.66%in DDDs.CONCLUSION:The marketing of quinolones will be further expanded.