RESUMO
Objective:To investigate the effect of repeated freezing and thawing on the clinical outcome of embryo transfer.Methods:A total of 48 cycles of twice frozen-thawed embryo (blastocyst) transfer in the reproductive medicine department, Shenzhen Luohu People′s Hospital from 2015 to 2020 were collected as the observation group, and 98 cycles of one frozen-thawed blastocyst transfer in the same period were randomly selected as the control group. The patient′s age, endometrial thickness, average number of transferred embryos, average number of high-quality embryos transferred, embryo recovery rate, implantation rate, clinical pregnancy rate, abortion rate, ectopic pregnancy rate, and live birth rate were compared.Results:There was no significant difference in age, endometrial thickness, number of embryos transferred and high-quality embryos transferred between the two groups (all P>0.05). There was no significant difference in embryo recovery rate, ectopic pregnancy rate, abortion rate and live birth rate between the two groups (all P>0.05). The embryo implantation rate and clinical pregnancy rate in the observation group were significantly lower than those in the control group (32.47% vs 55.70%, 39.58% vs 66.33%, all P<0.05). Conclusions:The clinical pregnancy rate was significantly lower than that of the control group after repeated vitrification of frozen-thawed embryo transfer, which may affect the subsequent developmental potential of embryos.
RESUMO
Objective To partially evaluate the scientific and technological activities of the Institute of Parasitic Diseases, China CDC, through publication analysis. Methods Information on the papers published in the last 5 years was collected since the renaming of the Institute in 2002. Number, category and being cited frequency of the publications were analyzed using the data of 2002 as baseline. Results 272 papers were published at 48 national and international periodicals during 2002-2006. The total number, the number of papers published at the core journals and at the SCI journals all increased in the year 2003-2006. Publications on research, review and report occupied 54.8%, 36.0% and 15.4% respectively, covered schistosomiasis, malaria, echinococcosis, filariasis, visceral leishmaniasis, food-borne and soil-transmitted parasitic infections, and newly emerging parasites with 44.5% and 15.4% on schistosomiasis and malaria respectively. 87.9%, 11.0% and 1.1% of the articles were published at the national, international and local journals respectively. The balance rate for the trends of papers submitted in 2002 was 6.5%, and 10.2%-15.4% in 2003-2006. 34 of the 272 papers were included in SCI journals. Retrieval through the web of knowledge revealed that 187 citations were found in the SCI papers with an average of 5.5; 6 papers were cited for more than 9 times each, occupying 27.3% of the overall citations, the highest being 84 citations. There was an unbalanced distribution of the publications among the departments of the Institute. Conclusion The results indicate that the research direction and content are in line with the tasks of the Institute and with the scientific merits of disease control; the level of research is increasing and some of the publications exert certain impact at home and abroad.