Skin cancer incidence in rural workers at a reference hospital in western Paraná

Abstract BACKGROUND: Skin cancer is common in Brazil and is related to sun exposure, among other risk factors. There are no data on the incidence of malignant skin neoplasm in rural workers in western Paraná. OBJECTIVE: To analyze the incidence and profile of rural workers who were diagnosed with skin cancer at a reference service in Cascavel, western Paraná, in the last five years (2011-2016). METHODS: This retrospective cross-sectional study was carried out through a review of the anatomopathological reports of rural workers diagnosed with skin cancer at Cascavel Oncology Center (CEONC), in Cascavel. The following variables were collected: year of diagnosis, age, gender, injury location and histological subtype. RESULTS: A total of 681 cases of malignant epithelial neoplasia were identified, with a higher frequency in the 61-70 age group. Data analysis showed an increase of about 210% in the occurrence of skin cancers in the last 5 years. The cephalic region was the most affected, and the most common histological subtype was nodular basal cell carcinoma. There was no association between gender and location. STUDY LIMITATIONS: This is a retrospective study and analysis of a secondary data bank. CONCLUSION: This study is a regional estimation of the incidence of cutaneous neoplasms and provides evidence of a considerable increase in the number of diagnoses in rural workers from western Paraná, Brazil. Moreover, it is possible to conclude that the sample group studied is at risk of developing skin cancer.

Uso de tacrolimus na nefrite lúpica / Use of tacrolimus in lupus nephritis

O lúpus eritematoso sistêmico é uma doença multissistêmica, de etiologia autoimune, que apresenta comprometimento renal em até 50% dos portadores. A nefrite lúpica é uma das mais sérias e comuns complicações do lúpus eritematoso sistêmico, especialmente nos pacientes não caucasianos. Drogas como ciclofosfamida (que faz a terapia de indução convencional, junto de corticosteroides), azatioprina, micofenolato de mofetila e hidroxicloroquina são essenciais para o tratamento desta complicação, porém ainda são necessárias outras opções terapêuticas em casos resistentes. O tacrolimus vem sendo utilizado recentemente no tratamento da nefrite lúpica, com escassas publicações a este respeito. Apresentamos revisão sobre o papel do tacrolimus na nefrite lúpica, utilizando artigos publicados nas principais bases de dados da literatura nacional e internacional, nos idiomas espanhol e inglês.(AU)

Systemic lupus erythematosus (SLE) is a multisystemic disease of autoimmune etiology that involves renal impairment in up to 50% of patients. Lupus nephritis (LN) is one of the most serious and common complications of systemic lupus erythematosus, especially in non-Caucasian patients. Drugs such as cyclophosphamide (which performs the conventional induction therapy along with corticosteroids), azathioprine, mycophenolate mofetil, and hydroxychloroquine are essential for the treatment of this complication, but other therapeutic options in resistant cases are also necessary. Tacrolimus has recently been used in the treatment of lupus nephritis, with few publications in this regard. We present a review of the role of tacrolimus in lupus nephritis using articles published in the main databases of national and international literature, in Spanish and English languages.(AU)