Neurologic outcome of Filipino children diagnosed with central nervous system infection

@# Neurologic infections are related to chronic and life-long neurologic impairment. We aim to describe the outcomes of Filipino children with neurologic infections upon, and within one year from discharge. This data will be useful in developing programs for the prevention and improvement of outcomes in children with neurologic infections. Methods: This is a multicenter, cross-sectional, retrospective cohort study at six tertiary hospitals across the Philippines within four years (2007-2010). A standardized report form was used to collect clinical profile and outcome using inpatient and outpatient records. Neurologic outcome was classified and staged at 3-, 6-, 9- and 12-months postdischarge. Results: A total of 480 patients were included in the analysis (mean age 4.7 ± 5.3 y), most were bacterial in etiology (275 cases, or 57.3%). Severity of illness on admission (Stage 3, p <0.001) and etiologic agent (viral, p <0.001) were correlated with poor neurologic outcome on discharge. Of the 154 patients that had follow-up, 91 cases were observed to have neurologic deficits (severe, 50; moderate, 29; and mild 12). Twenty patients had improvement of neurologic impairment on subsequent follow-up. Motor deficits (64 cases), cognitive disorders (26 cases) and seizures (17 cases) are the most common neurologic sequela

Reference values for nerve conduction studies in healthy newborns, infants and children in Philippine Children's Medical Center

@#<p style="text-align: justify;"><strong>BACKGROUND:</strong> Nerve conduction studies play a diagnostic role in the clinical evaluation of neuromuscular disorders in children. Reference ranges define the expected parameter values in disease-free children.</p><p style="text-align: justify;"><strong>OBJECTIVE:</strong> To propose reference values for sensory and motor nerve conduction and late responses in upper and lower limb peripheral nerves in Filipino children 5 years and below.</p><p style="text-align: justify;"><strong>METHODS</strong>: Sensory nerve conduction studies on median, ulnar, superficial peroneal, and sural nerves and motor nerve conduction and late response studies on median, ulnar, peroneal and posterior tribal nerves were done using standardized techniques among 100 healthy Filipino children.</p><p style="text-align: justify;"><strong>RESULTS:</strong> Subjects were stratified according to age groups. Reference values for the following parameters: (1) sensory conduction velocity and amplitude; (2) motor conduction velocity, amplitude and latency at distal sites;  (3) F-wave latency; and (4) H-reflex latency were summarized. These were expressed as mean ±standard deviation or median (range) for values that follow Gaussian and non-Gaussian distributions. The 5th and 95th percentile values were likewise reported. Age had direct correlation with various nerve conduction parameters. Height was directly correlated with F-wave parameters of median, ulnar and peroneal nerves but not posterior tribal nerve.</p><p style="text-align: justify;"><strong>CONCLUSIONS</strong>: Reference standards for nerve conduction studies of commonly tested nerves of Filipino children are presented. Values are comparable to reference ranges elsewhere except for the H-reflex latency which is higher in this study.</p>