RESUMO
Background & objectives: Human leucocyte antigen (HLA)-G plays a vital role in immunomodulation in rheumatoid arthritis (RA). The mounting evidence suggests a link between HLA-G gene polymorphisms, disease susceptibility and methotrexate treatment response. Various environmental factors influence the onset and progression of RA and its treatment outcomes. The aim is to identify the treatment response of HLA-G 3’ untranslated region polymorphisms to yoga-based lifestyle intervention (YBLI). Methods: In this eight-week single-blinded randomized controlled trial (CTRI/2017/05/008589), patients with RA (n=140) were randomized into two groups namely, yoga group or non-yoga group. Baseline genomic DNA was isolated using salting-out method. PCR-based methods were used for genotyping. The levels of soluble (s) HLA-G and disease activity were assessed by ELISA and disease activity score-28–erythrocyte sedimentation rate (DAS28-ESR), respectively, at baseline (day 0) and after eight weeks of intervention. Results: Low-producing sHLA-G genotypes, i.e. +3142GG and 14 bp ins/ins, showed a significant increase in sHLA-G levels after YBLI. The association analysis between HLA-G polymorphisms and treatment for RA showed no considerable differential treatment remission in either of the groups (P>0.05). The percentages of improvement were higher in the yoga group as compared to the non-yoga group in both the HLA-G +3142G>C and 14 bp ins/del polymorphisms irrespective of their respective genotypes. No significant association was found between sHLA-G levels and disease activity with respect to genotypes. Interpretation & conclusions: Yoga intervention results in improvement and reduced severity of RA in patients irrespective of the HLA-G 14 bp ins/del or +3142G>C polymorphisms. YBLI may be used as an adjunct therapy in RA independent of the genotypes
RESUMO
Functional orthopedic treatment seeks to improve skeletal and dental relationship of the jaws. The challenging task is to correctly position jaws antero-posteriorly and vertically with correct overbite, overjet and Centric relation. The Churro Jumper is an efficient, inexpensive and uncomplicated fixed flexible functional appliance. It is used to evaluate the efficacy of the Churro Jumper appliance in treatment of skeletal Class II malocclusion with retrognathic mandible. Churro Jumper contributes in correction of Class II molar relationship by dento-alveolar effects on both jaws. There was up-righting of maxillary incisors and proclination of mandibular incisors. Churro Jumper is clinically efficient as well as effective appliance to correct skeletal class II malocclusion. The only problem with this appliance is its frequent breakage and oral hygiene maintenance causing inconvenience to both patient as well as operator.
RESUMO
Background: India is amongst the top five countries in terms of absolute numbers of maternal deaths. In Uttar Pradesh MMR is even higher than national average. In spite of better utilisation of ante-natal services, pregnancy outcome is not significantly improving. Reason behind it is that worrying gaps in quality of antenatal care exist which lead to poor effectiveness of ANC in practice. Methods: In the present study quality of antenatal care services utilised by 286 recently delivered women (RDWs) in last one year in Shivrajpur block of district Kanpur was conducted from August 2012 to July 2013. A predesigned questionnaire was used for data collection. Information regarding age, parity, and detailed history of antenatal care & place of antenatal care were collected after taking verbal consent. Results: Majority (76.1%) of women were within 20 to 30 year of age who had delivered in last one year while 13.6% of women were within 20 year of age. In present study we find 91.9% coverage of antenatal care which was based on receiving at least one antenatal check-up. Majority (73.1%) of women received antenatal care from public facility (SC/PHC/CHC/Govt. Hospital). Out of 263 RDWs who received ANC, three-fourths had weight measurement (74.9%), their abdomen examined (76.4%) and hemoglobin estimation (69.6%) done. Less than two-thirds had height (60.8%) and blood pressure measured (66.2%). Nearly one of the two RDWs had urine examination (50.2%) and told about pregnancy complications & danger signs. Only 14.8% RDWs consumed 100 IFA tablet. TT injection was received by 79.5% of RDWs. Full ANC was taken by only 16.3% RDWs. Conclusion: Poor qualities of antenatal have a limited potential to affect maternal mortality. High-risk screening during antenatal care, as a means of identifying women for facility-based intra-partum care, is not effective for women who subsequently failed to obtain complete package of antenatal care.