RESUMO
Background: Cereal venous sinus thrombosis (CVST) is the formation of blood clot in the dural venous and/or sinuses, which drain blood from the ain. It is one of the commonest causes of stroke in young. In most cases it hypercoagulable factors are responsible for it. Materials & methods: prospective observational hospital based study in the department of Neurology, S.C.B. Medical College & Hospital, Cuttack, odisha from October 2015 to September 2017. Those patients with diagnosis of CVST with magnetic resonance imaging and venogram confirmation with thrombophilia profile were included in the study. Thrombophilia assay was done. They were treated with recent guidelines. All the data were analyzed according to spss software version 20.0. Results: Total 24 patients did the profile. Most common age group was 21–40 yrs. Protein s was the most common factor. Transverse sinus was the most common sinus. Multifactorial thrombofilia patients were more resistant to therapy. Conclusion: All the CVST patients must be exposed to thrombophilia profile assay. It will not only help treatment of the disease but also it will help in prognosticate the outcome. In our area protein S deficiency is the most common factor abnormality. Further large studies are needed to obtain further knowledge about the factors and their clinicoradiological correlation.
RESUMO
Febrile seizure is the most common seizures seen in infancy and pre-school era. They are mostly benign in nature. There are two categories of febrile seizures, simple and complex. Both the International League against Epilepsy and the American academy of paediatrics have published definitions on the classification of febrile seizures. Simple febrile seizures are mostly benign, but a prolonged (complex) febrile seizure can have long term consequences. Most children who have a febrile seizure have normal health and development after the event, but recent evidence suggests a small subset of children presenting with seizures and fever may have recurrent seizure or develop epilepsy. Diagnosis is solely clinical. But other causes of fever and seizure must be ruled out. Electroencephalogram, lumbar puncture and neuroimaging, all are to be used for specific indications but not routinely. Treatment consists of acute management and prophylaxis for further attack. This review will give an overview of the definition of febrile seizures, epidemiology, evaluation, treatment, outcomes and recent research.