[Comparison of short-term effect of oral Ritalin on emotional behaviors [fear and anxiety] of healthy and streptozotocin-induced diabetic rats]

Introduction and Aims: Fear is a normal reaction to dangers the main form of which is freezing [immobility and only breathing]. According to the studies conducted, the main area of fear is amygdala the disruption or destruction of which will result in lack of learning and expressing fear. The aim of this study was to compare the short-term effect of oral Ritalin on emotional behaviors [fear and anxiety] in healthy and streptozotocin-induced diabetic male rats

Materials and Methods: This experimental study was conducted on 48 immature male rats of about 3 weeks of age, classified into 8 groups of 6; namely the control group, groups of healthy rats with various doses of Ritalin [2.5, 5 and 10 mg/kg], the diabetic group and diabetic groups with various doses of Ritalin [2.5, 5 and 10 mg/kg] received via oral gavage. After 7 days [the short-term period], to investigate anxiety-like behaviors and other parameters related to it, rats were evaluated in Elevated Plus Maze [EPM]

Results: Results showed that in healthy groups, the higher was the dose of Ritalin, the more significant decrease was observed in fear relative to control group. In addition, in diabetic+Ritalin groups, the higher was the dose of Ritalin, the more significant decrease in fear was observed relative to diabetic group

Conclusion: According to the findings, the anti-anxiety effect of Ritalin [methylphenidate] can be confirmed

[Study of alcohol extract of sesame on wound healing of diabetic male wistar rats]

Introduction and Aims: Diabetes is a metabolic disorder, which is characterized by hyperglycemia resulting from defects in insulin secretion and impaired pancreatic function. Regarding to the medicinal properties of amaranth, this study was conducted to investigate the effects of amaranth on skin histomorphological changes in diabetic rats

Materials and Methods: In this study, 48 male Wistar rats were divided into four groups [control group, sham group, first experimental group, and second experimental group]. In these rats, an injured area of 3cm2 was created on the left spine. Wound healing was evaluated microscopically

Results: Wound healing in group that became diabetes using streptozocin, showed late recovery compared to normal wound healing in normal groups and wound healing in experimental groups treated with alcohol extract of sesame was accelerated compared to control group

Conclusion: Results of this study showed that alcohol extract of sesame causes accelerated skin wound healing in normal and diabetic samples