Influência da poluição atmosférica de São Paulo na fertilidade feminina de camundongos / Influences of air pollution on female fertility of mice

Neste estudo analisamos os efeitos da poluição atmosférica de São Paulo sobre a fertilidade feminina. Quatro grupos de camundongos fêmeas foram criadas em câmaras de topo aberto. A primeira câmara possuindo dispositivo de filtragem do ar (câmara limpa) e a outra sem tal dispositivo (câmara poluída). Operação cesariana foi realizada no 19º dia de gestação e avaliados o número de nascidos vivos, áreas de reabsorção, natimortos, número de corpos lúteos e falhas de implantação. Observamos um maior número de nascidos vivos na câmara limpa e maior número de falhas de implantação na câmara poluída. Estes resultados foram observados apenas nos animais expostos desde os primeiros dias de vida / In this study we analyzed the effects of São Paulo’s air pollution on female fertility. Four groups of female mice were placed in 2 uncovered chambers. The first chamber contained an air filter device (clean chamber) whereas the other one received ambient air pollution (polluted chamber). Cesarean section was performed on the 19th day of pregnancy and the number of born alive, reabsorptions, fetal deaths, corpora lutea and implantation failure rate were determined. We observed a higher number of born alive per animal in the clean chamber and a greater incidence of implantation failures in the polluted group. These results were observed only in animals exposed to air pollution at early age...

Prevalência de infartos renais em necropsias de chagásicos crônicos / Prevalence of renal infarction in necropsies of chronic chagasic patients

Renal infarction (RI) is usually secondary to arterial obstruction due to emboli originating from the heart. Chronic chagasic patients may present cardiac alterations originating from intracavitary thrombi, even without congestive heart failure (CHF). In this study RI incidence was comparatively evaluated in chronic chagasic individuals, in different anatomoclinic forms and in non chagasic individuals. There has been a review on necropsy reports of individuals aged 20 or over. In 259 necropsies, 78 (30.1 per cent) were chagasics, and 19 of them (24.4 per cent) developed RI, while 27 (15.0 per cent) of the non chagasic individuals presented RI. The ages of chagasics with RI were similar to those of non chagasic individuals. A significant prevalence of RI and thrombosis among chronic chagasic individuals has been found. A significantly higher prevalence of RI among chronic chagasics having CHF (52.6 per cent) was observed when they were compared to other forms of chronic Chagas disease and when compared to non chagasic individuals. It was concluded that RI was more frequent in chronic chagasic individuals, specially those who developed CHF, which probably played a role in the renal manifestations and systemic hemodynamic changes in those patients.