Can exercise affect reproductive and trophic hormones in girls?

To study the effect of exercise on the reproductive hormones [testosterone and estrogen] and trophic hormones [follicle stimulating hormone [FSH], luteinizing hormone [LH] and prolactin [PRL]] in girls of Sport Education at Mansoura University. Sixty students were randomized chosen from the student girls aged 18-20 years in the faculty of Sport Education at Mansoura University, Egypt, divided into 2 groups: Study group [30 students]: Control group [30 students]. The study group will practice only the physical exercises in the faculty curriculum for 2 years, 4 days/week. The control group will not practice any kind of sport. There is no significant statistical difference between the study group and the control group regarding anthropometric measurements. There is significant increase in testosterone level in the control group. Also there is significant increase in estradiol level in the study group. Regarding FSH, LU and prolactin there is no significant statistical difference in hormonal level in the study and control group. Non vigorous exercise in young girls is beneficial in decreasing testosterone level and increasing estradiol level, with no effect on trophic hormones [FSH. LH and prolactin]

Endothelin-1 and leptin as markers of intrauterine growth restriction

To explore the role of endothelin-1 [ET-1] and leptin in intrauterine growth restriction [IUGR] among preeclamptic and non-preeclamptic women. Forty patients with a pregnancy complicated by IUGR, 20 cases with severe pre-eclampsia and 20 cases non-preeclamptic were enrolled. Control group comprised 15 cases with uncomplicated pregnancy. Blood sample from umbilical artery and maternal venous blood were collected at the time of delivery for ET-1 and leptin levels. Mode of delivery, birth weight and Apgar score were recorded. The mean maternal and fetal ET-1 was significantly higher in pregnancies complicated by IUGR than in control group. The mean maternal leptin was significantly higher in preeclamptic patients when compared to nonpreeclamptic and control groups. Mean fetal leptin was significantly lower in patients than in control; however fetal leptin was corrected to fetal weight, it was insignificantly different in both groups. Maternal plasma ET-1 and leptin correlates with the degree of fetal growth restriction originating from deterioration of placental function. Maternal plasma leptin and ET-1 levels may reflect deterioration in fetal growth