Treatment of eneuresis in children with desmopressin [DDAVP]

The effectiveness of internasal instillation of the vasopressin analogue desmopressin [DDAVP] on the management of nocturnal enuresis was evaluated. Seventy-five children with primary enuresis were treated with desmopressin and thirty children were treated by placebo [same administration route using normal saline] serving as controls. The drug proved to be safe, more effective in older children and children who did not have enuresis every night. High doses [20 meg] gave better results than small doses [10 meg]