RESUMO
Background: digital subtraction angiography [DSA] is important diagnostic tool for evaluation of cerebral vasculature and provides essential information regarding hemodynamic status and collateral circulation in patients with stroke and vascular malformations, so it is ideal imaging method of choice for diagnosis of cerebrovascular diseases
Aim of the Work: to register all cases undergoing diagnostic cerebral angiography in Al-Hussein University hospital, neuro-intervention unit performed by a neuro-interventional team and evaluate the results, and outcome of this procedure
Materials and Methods: the present study is single-center study included all patients subjected to diagnostic cerebral angiography during period from 2006 to 2018. The study protocol was approved by the local Ethics Committee in Al-Azhar University. The patients had been recruited from Al-Hussein and Sayed Galal Hospital outpatient's clinics, internal departments and stroke units, which indicated for diagnostic cerebral angiography
Results: in the present study the mean age of patients with arterial stenosis was [55.47 +/- 8.80], 1049[51%] of them were males, 1009[49%] were females. In our study, mild stenosis was present in 254 [12.3%], moderate stenosis in 525 [25.5%], severe stenosis in 567 [27.6 %], subtotal occlusion in 315 [15.3%] and total occlusion in 397 [19.3%] of the patients which detected by DSA
Conclusion: arterial stenosis is more common than cerebral aneurysms and AVM in the patients who subjected to DSA. The presence of hypertension and diabetes mellitus were found to be significantly more prevalent among patients with arterial stenosis. However, the prevalence of hypertension and smoking were more prevalent in cerebral aneurysms
RESUMO
Solid lipid nanoparticles [SLN] have gained increasing attention as a colloidal drug carrier system, particularly for lipophilic drugs, because SLN combine the advantages of polymeric nanoparticles, fat emulsions, and liposomes but avoiding their disadvantages. Solid lipid nanoparticles are composed of high melting point lipid as a solid core coated by surfactants. The solid core allows the prolonged and controlled release of drugs and may protect incorporated drugs against chemical degradation. Lipid and surfactant nature are important in drug loading capacity, also affect size distribution and physical stability. In this study SLN were prepared by using different ratios of lipid/surfactant. The lipid nanopellets were produced by using the high speed homogenizer and by high pressure homogenizer. The particle size measurements were carried out using the photoncorrelation spectroscopy and laser diffraction. The results showed that the diameter of SLN were influenced by lipid matrix and surfactant nature as well as their concentrations. Particle size diameter was decreased as a function of surfactant concentration till it reach a certain limit after which it has no effect. Methods of preparation showed a potential effect on the presence of large particles and on the polydispersity index. In conclusion, physical characteristics of SLN are not only influenced by variation in process parameters but also by chemical nature of the used surfactant and lipid matrix that have a potential influence on the particle size distribution of SLN