Thermal stability of Ni [II] and cu [II] mixed ligand complexes derived from biologically important schiff bases, azoles and morpholine

Thermogravimetry [TG] and differential thermogravimefty [DTG] have been applied to the investigation of the thermal behavior of six mixed ligand complexes of Ni[II] and Cu[II] comprising the Schiff bases: o-hydroxyacetophenoneethanolimine [OHAE], N-salicylidene-o-iminophenol [SOP] and N-salicylidene-o-toluidine [SOT] as well as morpholine [Morph] and certain azotes. The azoles used are: 2-amino-thiazole [2-Atz], benzothiazole [Btz], 2-methylbenzothiazole [2-Mbtz], 3-methyl-2-selenoxobenzothiazole [3-Msbtz] and thiabendazole [Tbdz]. Heating the compounds first results in a release of the morpholine or the azoles. Kinetics of the decomposition reactions were studied using non-mechanistic equations

Reactivity of certain biologically important azoles and morpholine towards Ni [II] and Cu [II] complexes of O-hydroxyacetophenoneethanolimine and N-salicylidene derivatives

A number of mixed ligand complexes of Ni [II] and Cu [II] containing the Schiff bases: o-hydroxyacetophenoneethanolimine [OHAE], N-sallicylidene-o-iminophenol [SOP] and N-salicylidene-o-toluidine [SOT] as well as morpholine or the azoles: 2-aminothiazole, benzothiazole and 2-methylbenzothiazole has been prepared and characterized. The IR, UV-VIS spectra and magnetic moment measurements of the complexes were discussed

Some immunological studies in allergic rhinitis in children

Allergic rhinitis [AR] is a common disease in children. Eosinophils play an important role in the pathogenesis of allergic rhinitis by releasing toxic granule proteins which are directly involved in the late phase of allergic inflammation. For underst and ing the role of eosinophils in the pathogenesis of allergic rhinitis, the serum level of eosinophil cationic protein [ECP] was measured in children with AR. Blood eosinophilia and serum total IgE level were also evaluated in these patients. The study involved 50 children with AR and 22 normal children as control group. AR was diagnosed by history, skin tests and RAST. Blood sample was taken from each subject, absolute eosinophil count was done and serum used for measuring total IgE and ECP levels by monoclonal antibody based fluorometric assay. Allergen specific IgE antibody was measured by quantitative radioallergosorbent test [RAST] Serum ECP levels in the patient groups were significantly higher than those in the control group [P < 0.01]. All the patient groups studied showed significant high levels of serum total IgE [P<0.001] and total eosinophil count [P<0.01] compared with control group. The increased. level of ECP in patients with AR reflects eosinophil activation and this indicates the role of eosinophil degradation in the pathogenesis of allergic rhinitis. This result may help in developing pharmacological agents that can inhibit migration and /or degradation of eosinophils and hence control of the disease