Buccoadhesive tablets for delivery of verapamil hci: design, in-vitro analysis and in-vivo evaluation

Buccoadhesive controlled release verapamil HCI tablets have been prepared using mucoadhesive polymers namely; sodium alginate [Na Alg], xanthan gum [XG] and gum tragacanth [GT] either alone or in combination in different ratios 2:8, 8:2, 4:6 and 6:4. The prepared tablets were evaluated for their weight variation, thickness, hardness, friability and dissolution, content uniformity, swelling index, in-vitro adhesion, in-vitro drug release and in-vivo hypertension study. Tablets containing XG showed the highest swelling index and bio adhesive force. The maximum cumulative% released [100%] was observed in F7, F10 and FJl due to high percent of Na alg. The kinetics studies show that the release follows zero order kinetics except Fl that it obeyes a diffusion model The buccoadhesive verapamil HCI tablet had suggested being promising for the transmucosal delivery of verapamil HCI and allowing a controlled drug delivery for 6 hrs

Evaluation of the role of timolol 0.1% gel in myopic regression after laser in situ keratomileusis

To evaluate the efficacy of the concomitant administration of antiglaucoma medications namely timolol 0.1% gel in cases with myopic regression after myopic laser in situ keratomileusis [LASIK]. Prospective observational clinical trial. Ninty five eyes of 75 patients were included in this study prospectively. The mean myopic regression was-1.29 +/- 0.83 diopters [range-0.5 to-4.62] after myopic LASIK. The eyes were divided into two groups: 50 eyes administrated timolol 0.1% gel once daily for 12 months [treated group], and 45 eyes were age matched [control group]. We assessed the amounts of myopic regression in terms of changes in the refraction [spherical equivalent and astigmatism], intraocular pressure [IOP], pachymetry and the refractive power of the cornea measurements for all participants. The refractive error and visual acuity were similar between the two groups at baseline. The treated group had an improvement in spherical equivalent significantly from-1.29 +/- 0.83 to-0.94 +/- 1.07 diopters [P=0.012]. Astigmatism was changed from-0.94 +/- 0.53 to-0.86 +/- 0.60 diopters but this change was not statistically significant [P=0.20]. The IOP was decreased significantly from 12.6 +/- 1.9 to 9.0 +/- 1.1 mm Hg [P<0.001]. Central corneal thickness was changed from 425.6 +/- 19.86 to 429 +/- 18.1 micro m but not statistically significant [P=0.56]. The central corneal power decreased significantly from 37.2 +/- 1.8 to 36.4 +/- 1.3 diopters [P<0.05]. Timolol 0.1% gel was effective for reduction and improvement of myopic regression especially the spherical errors after myopic LASIK

Mastication in irradiated patients

Mastication among six irradiated completely edentulous patients with xerostomia were studied by measuring the masticatory efficiency and performance to determine their ability to chew foods after using a saliva substitute filled in reservoirs incorporated in lower dentures. Significant improvements in masticatory function after using a saliva substitute were realized. The patients were able to chew foods to a more finer particle size, faster with fewer strokes and less muscular effort. It was concluded that with a saliva substitute in cases of xerostomia, the denture is more comfortable, more efficient and less damaging to the supporting tissues