Oxygen detoxifying enzymes in uremic patients

Orygen free radical is a highly toxic agent which is liberated during many metabolic processes. This toxic product is detoxified through the oxygen detoxifying enzyme system, superoxide dismutase [S.O.D.], catalase and glutathione peroxidase. The above mentioned enzymes were found to be elevated in the early stage of chronic renal failure and the activity decreased with the development of the disease. The early affected enzyme is glutathione peroxidase