Protective role of dispercam against adverse effects of cefotaxime on lipid peroxidation and the activities of lipoxygenase and some antioxidant enzymes

Malondialdehyde [MDA] level and the activities of superoxide dismutase [SOD], catalase and lipoxygenase were determined in liver of guinea pigs treated with: 1-Cefotaxime, 2-[Cefotaxime plus dispercam], 3- dispercam, and compared their results with the control data. Cefotaxime increased both the level of MDA and the activities of SOD, catalase and lipoxygenase enzymes as compared with the normal control data. However, the treatment of guinea pigs with cefataxime plus dispercam decreased both level of MDA and the activities of SOD, catalase and lipoxygenase enzymes as compared with the data of cefotaxime treatment, i.e., Dispercam treatment decreased the side effects of cefotaxime treatment. The results also showed that, the treatment with dispercam only decrease the activities of SOD, catalase and lipoxygenase and also the level of MDA as compared with the normal control data

Effect of sulphur compounds on the rat brain and liver monoamine oxidase-B

Rat brain and liver monoamine oxidase-B is inhibited when incubated with sulphur compounds [thiourea, sulphanilamide, sulphagunidine and sulphadiazine]. These compounds inhibit the monoamine oxidase-B enzyme reversibly with time and concentration dependent response. However, methionine has no effect on the enzyme. The values of K[m] and V[max] were determined from the lineweaver-Burk plot