RESUMO
Rett Syndrome is a neurodevelopmental disorder, one of the least commonly occurring autism spectrum disorders [ASD], affecting mainly females. To describe features and molecular specificities of Rett syndrome. To identify articles for this review, a Pubmed search was conducted using the following keywords: Rett syndrome, regression,mutation, stereotypes. This syndrome is characterized by cognitive impairment,communication dysfunction, stereotypic movement disorder, and growth failure. It is generally caused by mutations in the MECP2 gene. Rett Syndrome has a prevalence ranging from 10-20 000 females. Specific treatement is not available, but patients need a careful planning for long-term care, with multidisciplinary approaches
RESUMO
Attention-deficit hyperactivity disorder [ADHD] is a heterogeneous disorder currently defined by clinical history and behavioral report of impairment. The Attention Network test [ANT] gives measures of different aspects of the complex process of attention. We ask if children with Attention Deficit Hyperactivity Disorder [ADHD] will show a characteristic pattern of deficits on this test. The sample included 40 children [M=9 years] who performed the Attention network test". Children with an ADHD diagnosis [N=20] were compared to a control group [N=20]. The group of children with ADND showed slower reaction times in all conditions [mean RT=866sns; SD=234, 063]. Children with ADHD showed a significant impairment in their executive control system compared to healthy subjects, with slower reaction times in incongruent conditions and lower accuracy scores [RT=1064 ms; F[1.38] p=0.02]]. Our results showed that spatial orienting and alerting in ADHD was no different than controls [p=0, 68]. ADHD group showed a greater variable response [p=0, 0001]. The present study showed that impairment in executive control system and variability measures are the characteristic pattern of deficits in children with ADHD