RESUMO
Several studies performed on tumours from different organs have shown that DNA ploidy is art additional predictor for survival. However the significance of DNA ploidy as an independant prognostic for patients with renal cell carcinoma [RCC] is less clear. Therefore purpose of this study is to assess if DNA flow cytometry data in RCC valuable prognostic information. One hundred sixty-eight consecutive patients were selected from 226 patients with RCC who underwent nephrectomy at our institution between 1983 and 1995. All patients were free of metastatic or locally irresectable disease preoperatively. DNA content was analysed by flow-try. DNA ploidy of the tumour tissue was compared with tumour pathologic stage [TNM 1997], grade, histological subtypes and disease related survival rates. Different prognostic factors were studied us-both univariate and multivariate analyses. Of the 168 tumours analysed, 92 [54.8%] displayed diploid and 76 [45.2%] had aneuploid pattern. Statistical correlations were between DNA ploidy pattern and each of tumour size, stage and grade. Significant high incidence of tumour recurrence was observed among patients with aneuploid tumours [46%] when compared with that diploid population [17, 4%] [P<0.001]. According to univariate analysis, tumour size, stage, grade and DNA ploidy had significant impact on patients outcome. On rnultivariate analysis, DNA ploidy in addition to tumour stage and grade were sign4ftcant independent prognostic factors. DNA ploidy is a reliable prognostic factor for RCC and yields considerable information for patient management and predicting clinical outcome