Serological detection of Toxoplasma gondii in chronic renal failure patients and renal transplant recipients

Toxoplasma gondii antibodies were detected in 78 patients with renal disease by ELISA. Patients were classified according to the renal status; chronic renal failure patients not on haemodialysis [G1=19], chronic renal failure patients on regular haemodialysis [G2=30], renal transplant recipient [G3=29] and 13 normal controls. Anti-Toxoplasma IgG and IgM antibodies were 36.8% and 10.5% in renal failure patients not on haemodialysis, 56.7% and 16.7% in patients on regular haemodialysis and 69% and 24.1% in renal transplant recipients versus 23.1% and 0% in controls with statistical significant difference for Toxoplasma IgG antibodies only. Anti-Toxoplasma IgG antibodies levels of G3 were lower than that of Gl. It was observed that the more the exposure to dialysis, the more the risk of toxoplasmosis. It was found that 85.71% of renal transplant recipient seropositive cases for anti-Toxoplasma IgM antibodies were detected in one year post-transplantation and 14.28% of cases after the first year of transplantation

Risk factors predisposing to toxoplasmosis in chronic renal failure patients and renal transplant recipients

This work evaluated risk factors predisposing to toxoplasmosis in chronic renal failure patients and renal transplant recipients. The present study included 91 cases classified according to their renal status into four groups; control group, renal failure patients not on haemodialysis, renal failure patients on regular haemodialysis and renal transplant recipients group. The age groups [<20] and [30-] had the highest positivity for anti-Toxoplasrna IgG and IgM antibodies in comparison to the other age groups. The results showed no sex difference in positivity rate for anti-Toxoplasma IgG and IgM in groups. There was no significant difference between groups regarding risk factors for contracting toxoplasmosis, clinical presentation suggestive of toxoplasmosis and diabetes mellitus. There was significant difference between all groups as regarding intake of immunosuppressiye drugs and blood transfusion