Synthesis and evaluation of some new 2.4- [1H.3H] -quinazolinedione derivatives as potential analgesic and anti-inflammatory agents

A series of 1-[3-trifluoromethylphenyl]-2, 4-[1H,3H]- quinazolinedione derivatives was synthesized as potential analgesic and anti- inflammatory agents. Structures were confirmed by elemental analysis and spectral data. Five compounds were tested for analgesic and anti- inflammatory activities. Two compounds II and VI exhibited significant analgesic and anti-inflammatory activities compared with flufenamic acid