Nutrition Education intervention in dyslipidemic children and adolescent with insulin-dependent diabetes mellitus [IDDM]

Diabetes mellitus is the most common endocrine metabolic disorder of childhood and adolescence with important consequences for physical and emotional development. This study was designed to detect the effect of diet therapy [through nutrition education program] on lipid profile and blood glucose level in diabetic children. The study was carried on 45 diabetic children aged between 8-15 years old at diabetic nutrition clinic of nutrition institute in Cairo from 2003-2005. Children included in the study were divided into two groups: insulin dependent dyslipidemic group [IDDM] [diet control/ group] and insulin dependent non dyslipidemic [control group]. All were subjected to full dietetic history by the 24 hour recall for 3 days, thorough clinical examination, they were evaluated for plasma lipids, lipoproteins, fasting blood glucose [FBG] and glycated hemoglobin [HbA[12] levels. The dyslipidemic were measured after three months for the previously measured parameters. The nutrition education process was performed and continued on weekly intervals for three months. There was significant decrease in serum cholesterol and triglyceride levels in the study group after the program, and insignificant increase in serum HDL and decrease in serum LDL. Also, there was insignificant decrease in FBG but there was statistically significant decrease in HbAl after the program. These changes occurred in parallel with increases in intakes of protein and total calories with adequate carbohydrate and sometimes a reduction in intakes of total fat. Nutrition therapy for children with IDDM is essential to improve measures of glycemic control and lipoprotein mediated risk for dyslipidemia. More innovative approaches to achieve lifestyle changes are required to meet current recommendations which are likely to produce greater beneficial changes than those observed in this study

Hypolipidimic effect of some medicinal plants on diabetic rats

Our aim was to evaluate the hypolipidimic effect of aqueous extract of a famous mixture used in Saudi Arabia folk medicine that consists of Nigella sativa, Commiphora myrrha, Boswellia carterii Birdw, Ferule assa-foetida and Aloe vera and also the extract of each plant alone on alloxan induced diabetic rats. The present study was carried out on 80 adult male albino rats [120 +/- 20 g.b.wt.], the rats were divided randomly into 8 groups, the first group served as control group, the second group as alloxan induced diabetic rats, the third group was diabetic rats treated with mixture of folk medicinal plant [0.01g /100 g b. wt.] ,the fourth group: diabetic rats treated with Nigella sativa [0.01g /100 g b. wt.], the fifth group: diabetic rats treated with Aloe vera [0.005g /100 g b. wt.], the sixth group: diabetic rats treated with Ferule assa-foetida [0.01 g /100 g b. wt.], the seventh: diabetic rats treated with Boswellia carterii Birdw [1ml/100 g b. wt.] and the eighth group: diabetic rats treated with Commiphora myrrha [0.01 g ml/100 g b. wt.]. Serum total lipid, serum total cholesterol, LDL-cholesterol, and triglyceride recorded significant increases in diabetic, Nigella sativa, Commiphora myrrha, Boswellia carterii birdw and Aloe vera treated group. While the mixture and Ferule assa-foetida treated group, showed insignificant changes in serum total lipid, triglyceride, serum total cholesterol and LDL-cholesterol. On other hand, the mixture treated group and Ferule assa-foetida treated group showed significant decreased in the previous parameters. The serum HDL cholesterol was significantly reduced in diabetic group throughout the experimental periods, otherwise, all treated group revealed insignificant changes till the end of experiment when compare with undiabetic rats. The aqueous extract of a mixture consists of Nigella sativa, Commiphora myrrha, Boswellia carterii Birdw, Ferule assa-foetida and Aloe vera are useful for improvement of the lipid profile of alloxan induced diabetic rats from each plant alone