RESUMO
Background: Pseudomonas aeruginosa is a gram negative bacillus. Infection with these bacteria usually occur! in patients who hospitalized due to: need for prolonged stay in ICU, those who have intravascular catheters, or indwelling urinary catheters
This Study investigates in vitro susceptibility of pseudomonas aeruginosa which were isolated from patients with UTI to doxycycline, tigecycline, ceftazidime, cefepime, piperacillin/tazobactam, impipenem, meropenem, colistin, ciprofloxacin, nitrofurantoin, amikacin] with standard disk diffusion. Comparing the, susceptibility results of disk diffusion with E.test for doxycycline and tigecycline is another aim. Other purpose of this study was to define MDR pseudomonas aeruginosa susceptibility to doxycycline and tigecycline
Methods: Sixty pseudomonas aeruginosa which was isolated after biochemical and bacteriological test, were entered to study and susceptibility to above antibiotics was tested by disk diffusion. For doxycycline and tigecycline antibiogram by two methods were performed: disk diffusion and Etest
Result: Maximum susceptibility was observed for colistin =95% followed by sensitivity in decreasing order for these antibiotics .Meropenem 76% Imipenem= Cefepime
Conclusion: In vitro susceptibility of isolated pseudomonas aeruginosa to studied antibiotics [with exception of colistin] was less than 80% even for carbapenems
Disk diffusion for doxycycline and tigecycline wasn't effective for differentiation intermediate resistance from sensitive. Calculation of cohens Kappa for agreement was moderate. Most of MDR pseudomonas aeruginosa was resistant to doxycycline and tigecycline