effect of tranexamic acid on cardiac surgery bleeding

Serious bleeding in cardiac surgery leads to re-exploration, blood transfusion and increases the risks of mortality and morbidity. Using the lysine analogous of antifibrionlytic agents are the preferred strategy to suppress the need for transfusion procedures and blood products. Although tranexamic acid has been very influential in reducing the transfusion requirement after operation, tranexamic acid induced seizures is one of the common side effects of this drug. Due to inhibiting the fibrinolysis, thrombotic events are other possible side effects of using tranexamic acid. There are no certain results regarding decreasing the mortality rate by using the drug but it is identified that tranexamic acid does not increase the mortality. In this article, we aimed to review the literature on using tranexamic acid in cardiac surgeries

Cytotoxic effect of a new endodontic cement and mineral trioxide aggregate on L929 line culture

The aim of this study was to compare the cytotoxicity of Mineral Trioxide Aggregate [MTA] and a New Endodontic Cement [NEC] on L929 mouse fibroblasts. Different dilutions [Neat, 1/2, 1/10, 1/100] of fresh and set materials placed adjacent flasks of L929 in DMEM medium. Cellular viability was assessed using MTT assay in three time intervals [24, 48, and 72 h after mixing]. Differences in mean cell viability values between materials were assessed by using the One-way ANOVA and Bonferoni post-test. Optical microscopic analysis of morphology of the untreated control and the cementtreated cell cultures were carried out in all experimental periods. It was indicated that there was not a significant difference in cytotoxicity among the materials of test and between them and the control group. However, there was a statistically significant difference between different time intervals within each group [P