Acute oral toxicity study of ivy-thyme syrup in albino rats

This study was designed to assess the acute oral toxicity of Ivy-Thyme syrup in rats. The tested product was administered at a dose level of 3, 6 and 12 mL/kg. All animals were examined for clinical signs of ill-health or mortality at 1,2,4 and 8 hours after oral administration, and twice daily thereafter for 14 days. At the end of the study, all rats were alive with normal appearance and showed body weight gain during the study. The kidneys and livers of the sacrificed animals appeared normal. Ivy-Thyme syrup having 0.75% Ivy leaf dry extract and 5% thyme fluid extract was found to be non-toxic by the oral route at a dose level of 3,6 and 12 ml/kg in female rats under the conditions of this study

In vitro xanthine oxidase inhibition by selected Jordanian medicinal plants

In the present study, 18 Jordanian medicinal plants were evaluated for their Xanthine Oxidase [XO] inhibitory potential. Their aqueous extracts, prepared from used parts, were tested in vitro, at 200 micro g/mL concentration, for their inhibition potencies expressed as% inhibition of XO activity. Five of the tested plants were found most active [% inhibition more than 35%] and their inhibition profiles [dose-dependent] were further evaluated by estimating the IC[50] values of their corresponding extracts. These plants were Hyoscyamus reticulates L. [IC[50] = 12.8 micro g/mL], Achillea fragrantissima [Forssk.] Sch. Bip. [197.6 micro g/mL], Pimpinella anism L., [300.4 micro g/mL]. Origanum syriacum L. [317.0 micro g/mL], and Origanum vulgare L. [403.9 micro g/mL]. Moreover, five more plants showed XO inhibitory activity in the range of 14-30%. Namely: Daphne linearifolia L. [29.5% inhibition], Hibiscus sabdoriffa L. [19.44], Aristolochia maurorum L. [15.6%], Citrullus colocynthis [L.] Schr. [14.4%], and Laurus nobilis L. [13.97%]. Considering the results of the present screening study, many of the investigated plants species can be used as potential sources of natural XO inhibitors that can be elaborated as successful herbal remedies for gout, arthritis and other XO-related disorders