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The aim of this study was the effect of Myrtus communis extract on liver enzymes and blood biochemical factors in diabetic adult male rats. This study has been carried out experimentally and completely random. Seventy adult male Wistar rats were divided in 7 groups including: control which received no treatment, sham who received 2 mL of distilled water, the 1st, 2nd and 3rd experimental groups which received 0.75, 1.5 and 3 mg/kg Myrtus communis leaf extract respectively, the 4th experimental group as the diabetic control group who received streptozotocin [60 mg/kg] and the 5th experimental group as the diabetic treatment group who received 3 mg/kg of extract. This experiment lasted 14 days with prescript orally. After this period, all the rats, were weighted, anesthetized and blood samples were taken from the heart centrifuged and sera were evaluated for the concentration of various factors. In addition liver were removed and sliced. According to the obtained results, the plasma concentration of liver enzyme [alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase], cholesterol and glucose presented a significant decrease at [p
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In the present research, the effects of hydro-alcoholic extract of Zingiber officinale [ginger] on treating lead-poisoned kidney of neonatal rats was studied. This research was conducted as a laboratory work. The neonatal rats were divided into 7 groups of 10 samples. The first control group received no treatment. The second control group received 0.1 mg of distilled water. As an experimental group, the one received an amount of 0.6 g/l lead. The fourth group received only 2 g/kg body weight of hydro-alcoholic extract of ginger. Groups 5 to 7 each initially received 0.6 g/l lead and then amounts of 0.5, 1 and 2 g/kg hydro-alcoholic extract of ginger. The injections were administered via oral gavage during 10 consecutive days. According to the obtained results, the body and kidney weights showed a significant reduction in experimental groups that had received amounts of 1 and 2 g/kg in comparison with the group that had received lead. The kidney weight of the group that had received only extract showed no significant difference in comparison with the control group. As for the body weights, however, it showed a significant increase. Moreover, the body and kidney weights of the lead-injected group showed a significant increase in comparison with the control group. Lead can cause damage to kidney tissues. Due to its antioxidant and protective effect, ginger can be a medication to nephrotoxicity of lead and prevent kidney tissues from destruction
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The aim of this study was to evaluate diagnostic value of urinary polymerase chain reaction [PCR] in urogenital tuberculosis [UTB]. In 33 patients with confirmed diagnosis of UTB by urine culture and/or acid-fast staining, clinical symptoms and laboratory and radiological findings were evaluated. For each patient, 3 consecutive urine samples were examined by PCR for Mycobacterium tuberculosis and the results were compared with the standard microbiological methods and radiological findings. The mean interval between the appearance of the symptoms and the diagnosis was 12.3 A +/- 12.2 months. Symptoms were irritative bladder symptoms such as dysuria and diurnal or nocturnal frequency [51.5%], flank pain [27.3%], microscopic hematuria [18.2%], gross hematuria [9.1%], and suprapubic pain [9.1%]. The laboratory findings included hematuria [27.3%], pyuria [12.1%], and hematuria with pyuria [48.5%]. Diagnosis of UTB was made in 19 patients by positive urine culture for MT in 19 patients [57.6%], positive acid-fast staining in 6 [18.2%], and both in 8 [24.2%]. Intravenous urography showed abnormal findings in 16 patients [61.5%], including pyelocaliceal dilatation [26.9%], ureteral stricture and hydroureter [23.1%], multiple small caliceal deformities [15.4%], severe parenchymal destruction [11.5%], autonephrectomy [11.5%], and calcification [7.7%]. Urinary PCR was positive in 16 patients [48.5%] and in 10 [62.5%] with abnormal findings on intravenous urography. A high index of suspicion is necessary for diagnosis of UTB even in patients with nonspecific manifestations. Urinary PCR is recommended for instant diagnosis and screening before further examinations, but it cannot be the sole diagnostic modality for diagnosis of UTB
Assuntos
Humanos , Masculino , Feminino , Reação em Cadeia da Polimerase , Mycobacterium tuberculosis , Urina , UrografiaRESUMO
The shortage of cadaveric donors for kidney transplantation has led to the expansion of the criteria used for donor selection, such as the use of pediatric cadaveric donors. In this study we reviewed our results of en bloc kidney transplantation of pediatric cadaveric donors to adults. From May 2001 to May 2005, 245 cadaveric kidney transplants have been performed in our hospitals. Seven of these were en bloc kidney transplantations in adult recipients from marginal pediatric donors [age < 5 years, donor weight < 15 kg, high creatinine clearance, or kidney length < 8 cm]. We reviewed their records. Follow-up [range, 3 to 24 months] included ultrasonography, dimercaptosuccinic acid renal scintigraphy, and magnetic resonance imaging. Serum levels of creatinine ranged between 0.8 m/dL to 1.9 mg/dL during the follow-up period. One patient died of myocardial infarction 3 months postoperatively. One-year graft and patient survivals were both 85.7%. Complications included acute tubular necrosis in 1 patient [managed by conservative therapy and dialysis for 2 weeks], renal vein thrombosis in 1 [treated by anticoagulation], and subcutaneous hematoma in 1. There were no urologic complications. Median size of the grafts was 7.2 cm preoperatively that reached 9.6 cm, 3 months postoperatively [P =.018]. Twelve months following operation, the median size of the grafts reached 11 cm [P =.045]. En bloc pediatric kidney transplantation is a safe and suitable alternative for adult recipients. One-year graft and patient survivals are acceptable and complication rate is low