Epidemiological study of the patients referred for thalassemia diagnosis using chorionic villous sampling [CVS] in genetic laboratory of Dastgheib hospital, Shiraz, 2011

Pre-natal diagnosis is the most effected way to prevent genetic diseases in a society. The aim of this research was to show the prevention level of the birth of the children with major thalassemia disorder and the demographic condition of the people referring to the Shahid Dastgheib Genetic Center in Shiraz for the pre natal diagnosis. The present research was a cross- sectional [descriptive, analytical] one. In this study, the amount of sampling was done by census in a way that all the case [372 cases] related to the year 2010. The questionnaire was prepared based on the information present in the files. In order to compare the quantitative and qualitative variables, two sample t - test and K sample t- test were used. Out of 372 fetuses tested, 25.5% had major thalassemia, 48.7% minor thalassemia, 0.8% intermediate, 1.3% sickle cell, and 23.7% were healthy. All the cases diagnosed with thalassemia were introduced for abortion, and abortion was carried out. Major thalassemia was more prevalent in Lore tribes [32.9%], which was more in comparison to the members of others tribes. In order to prevent major thalassemia, it is important to identify the gene carriers and prevent their marriage. Nevertheless, in many places in the country, especially in the villages and rural areas, the couples do the experiment after they have already gotten emotionally involved and made the arrangements to get married; therefore they're unwilling to stop the marriage. As a result, post-nuptial CVS during pregnancy is crucial

Comparison of the prevalence and the causes of unwanted pregnancy in women under 35 versus over 35 years

The aim of this study is to compare the incidence of unwanted pregnancies in women under 35 and those over 35 years, compare the results with the previous data, and also to determine the causes of unwanted pregnancies in these women. This cross-sectional study [descriptive - analysis] is performed on 400 pregnant women who had referred to the laboratories of Shiraz. Ten laboratories were randomly selected from different parts of Shiraz. The subjects were interviewed during the period of three months they referred for the result of their pregnancy test. Questionnaire included demographic information, how to use the methods of contraception, how to treat women with unwanted pregnancies, and the history of pregnancy. The chi-square tests, t-test, and logistic regression were utilized in order to compare two groups of women under 35 and over 35 and also to determine the factors related to unwanted pregnancies. In this study, the prevalence of unwanted pregnancies in women under study was 14.7%. The incidence of pregnancy in women under 35 and those over 35 was 13.3% and 33.3%, respectively. The difference between the groups was found to be statistically significant [p=0.01].The percentage of unwanted pregnancies has reduced in Shiraz and this is indicative of the success of family planning. However the percentage of unwanted pregnancies in women over 35 is still high. Due to the fact that these women use unreliable methods training courses should be planned for them