[Comparison of serum level of CRP and platelet in acute perforated and non-perforated appendicitis in Imam Hossein hospital of Shahroud in 2011]

Appendicitis is one of the most common and important surgical problem and its early diagnosis is very important. Diagnosis of appendicitis is based on clinical examination and laboratory tests. Therefore, we decided to take a small step in recognition of problems by evaluation of CRP and Platelet level in diagnosing of non-perforated and perforated appendicitis patients. This cross- sectional study was done on 160 patients with diagnosis of appendicitis on 2011. Patients were examined and then were operated in operation room by standard method. The patients were divided in two groups in terms of perforated and non-perforated appendicitis. Data were analyzed by SPSS software and related statistical tests. Of 160 patients, 124 patients [77.5%] were male and others were female. Forty nine patients [30/6%] had perforated appendicitis and 111 patients [69/4%] non-perforated appendicitis. Mean age of participants in the perforated and non-perforated groups were 28.35 +/- 20.15 and 27.75 +/- 21.65 years, respectively. There was no significant difference between two groups regarding sex distribution, but risk of perforation increased by aging [odds ratio: 1.1] CRP levels were significantly higher in the perforated group than non-perforated appendicitis group [p<0.003], but platelet levels were similar between two groups. This study showed that it is possible to use CRP for diagnosing of acute and perforated appendicitis, but it may never be replaced exact clinical examination and sonography

[Comparison the analgesic effect of naproxen suppositories with intra wound injection of markain after inguinal hernia surgery]

Anti-inflammatory drugs are used for reducing the pain after surgery especially in minor surgery and local anesthesia drugs, especially Markain, is also employed. Regarding performing little studies about the comparison of these two kinds of drugs, this study was done for comparison two methods. This double-blind randomized clinical trial study was done on 198 patients with inguinal hernia. Patients were divided into case group [intra wound Markain] and control group [the suppository of naproxen]. Surgery was done with standard method [Liechtenstein] and the severity of pain was assessed by the visual analogue scale [VAS] in one, six and 24 hours after surgery. Data were analyzed by SPSS- ver16 software. Mean age in case group were 52.6 +/- 5.7 years and in control group were 53.7 +/- 4.9 years. Mean pain intensity in the first and 6[th] hours in case group were 6.3 and 4.6 and in control group were 3.9 and 2.9, respectively [P<0.001]. The pain immediately and 24 hours after surgery were similar in both groups and there was no significant difference between the two groups. Need to opioid analgesics was further reduced in the naproxen group one and six hours after surgery. Although both methods were effective in reducing postoperative pain and less expensive, but naproxen suppositories was more effective pain reliever for optimal pain control, especially in the first and six hours after surgery and is more effective in reducing pain intensity than Markain. Naproxen also reduces the need to deal with housing has been opioid analgesics