RESUMO
To study the presence of the alloantibodies and their relationship with the number of transfusions. Two hundred subjects undergoing regular blood transfusions with at least 5 pints of blood within last six months were included in the study. Out of 200 patients, 140 [70%] were transfusion depended thalassaemics, 20 [10%] were haemophilics receiving multiple transfusions, 20 [10%] patients were of aplastic anaemia and 20 [10%] patients were with chronic renal failure undergoing haemodialysis. Antibodies were detected in 9/200 [4.5%] subjects. Ninety four patients received 5-50 transfusions, 2.13% developed alloantibodies. Sixty five patients received >50-100 blood transfusions, 6.15% developed alloantibodies. Forty one patients received >100 blood transfusions, 7.31% developed alloantobodies. Frequency of red cell alloantobodies in our transfusion dependent patient population is 4.5%. The risk of developing alloantobodies increased with increasing number of blood transfusion irrespective of underlying disorder.