Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Adicionar filtros








Intervalo de ano
1.
Journal of the Egyptian Society of Parasitology. 2016; 46 (1): 201-208
em Inglês | IMEMR | ID: emr-180175

RESUMO

Congenital toxoplasmosis is associated with important morbidity and mortality. Since vertical transmission of Toxoplasma gondii can occur in acute cases, antenatal screening for recent infections is vital. Accurate determination of acute toxoplasmosis requires a combination of immunoassays, usually not routinely applied for screening purposes. This study evaluated the anti-T. gondii [IgG+IgM]/IgM prenatal screening procedure by IgG avidity assay


The routine prenatal screening for [IgG+IgM] anti-T. gondii by indirect hemagglutination [IHA] in serum samples was done of 2247 pregnant women who attended two hospitals between 2011 and 2013 revealed 487 [21.7%] positive samples. Examination of IHA-positive sera by IgM and IgG/IgG-avidity concurrent ELISA tests revealed 7 positive and 3 border-line IgM-ELISA titers during the initial check-up of 10 women, who were then followed up at 3-4 week-intervals. Among these, 4 [40%] showed simultaneous high avidity IgG antibodies, indicating distant infection by the parasite, and no anti-T. gondii specific IgG could be detected in follow-up sera of two cases [20%], indicating false IgM initial positive results. Only 4 [40%] women showed simultaneous IgM and low avidity IgG antibodies indicating active infections. Avoidance of an overdiagnosis of acute toxoplasmosis Anti-T. gondii [IgG+IgM]/IgM prenatal screening must be supplemented by a discriminative test like IgG avidity ELISA


Assuntos
Feminino , Humanos , Diagnóstico Pré-Natal , Afinidade de Anticorpos , Ensaio de Imunoadsorção Enzimática/métodos , Anticorpos Antiprotozoários/sangue , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Complicações Parasitárias na Gravidez/diagnóstico
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA