Specific circulating Schistosomal immune complexes among children with arthropathy

Sixty children were chosen from Pediatrics Department of Zagazig University and 14 age-matched healthy children were chosen to be included in this study.The children were classified into 4 groups: The first group consisted of 28 children infected with active schistosomiasis and arthoropathy; the second group included 18 children with schistosomiasis only without arthoropathy; the third group included 14 children suffering from arthoropathy without schistosomiasis.The fourth group consisted of 14 apparently healthy children and served as a control group. A significant high percentage positivity of specific circulating schistosomal immune complexes was found among the group of schistosomal arthoropathy versus the other groups. Moreover, a significant higher mean optical density readings was found among the same group of schistosomal arthoropathy. Furthermore, a significant positive correlation between percentage positivity of CIC and intensity of infection was recorded. From these results it appears that schistosomiasis plays a significant role in the pathogenesis of arthoropathy among children. Moreover, ELISA assay, using monoclonal antibody, is a highly sensitive test in detecting specific CIC in children with schistosomiasis

Specific circulating Schistosomal immune complexes among children with arthropathy

Sixty children were chosen from Pediatrics Department of Zagazig University and 14 age-matched healthy children were chosen to be included in this study. The children were classified into 4 groups: The first group consisted of 28 children infected with active schistosomiasis and arthropathy; the second group included 18 children with schistosomiasis only without arthoropathy; the third group included 14 children suffering from arthropathy without schistosomiasis. The fourth group consisted of 14 apparently healthy children and served as a control group. A significant high percentage positivity of specific circulating schistosomal immune complexes was found among the group of schistosomal arthoropathy versus the other groups. Moreover, a significant higher mean optical density readings was found among the same group of schistosomal arthoropathy. Furthermore, a significant positive correlation between percentage positivity of CIC and intensity of infection was recorded. From these results it appears that schistosomiasis plays a significant role in the pathogenesis of arthoropathy among children. Moreover, ELISA assay, using monoclonal antibody, is a highly sensitive test in detecting specific CIC in children with schistosomiasis