RESUMO
A study on 2788 cases with different disorders of genetic origin was done to establish the association between these disorders, consanguinity and inbreeding coefficient. Inbreeding coefficient in such a massive number of cases was estimated for the first time in Egypt, and the size of homozygosity in such different disorders was evaluated. Marked and significant high values of parental consanguinity and average inbreeding coefficient were obtained among the studied cases when compared to those of the control. This strongly confirmed that consanguinity had a determinant effect in transmission of recessive, intermediate and multifactorial traits. It also provided further support that there is a strong detrimental genetic element[s] which manifested or expressed phenotypically on homozygosity either directly through mutant gene transmission [as in recessive and intermediate traits] or indirectly through genetic predisposition [as in multifactorials]. The results were illustrated and discussed